DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and Pde11a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	NP_543169.1	Gene:	Pde11a / 140928	RGDID:	621793	Length:	935	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	387/945 - (40%)
Similarity:	540/945 - (57%)	Gaps:	91/945 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ASSSKPLTNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNRPAVTNR 94
            ||..:|...||:..|.|:|.|..      |.|.||.|..|:               |:.||....
  Rat    48 ASDLRPALAGASSLAQSSARGST------GIGGGAGPQGSA---------------NSHPASGGG 91

  Fly    95 SSETKLMTPTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEK 159
            .|....::|:.:|.|......|.:||       |..|.|   :.::.....|.|.::|:
  Rat    92 ESAGVPLSPSWASGSRGDGNLQRRAS-------QKELRK---SFARSKAIHVNRTYDEQ------ 140

  Fly   160 WLTERAPPEALSRLQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRR 224
             :|.|| .|.||.::.....||....|..|:.:....:.:...:.|..|.::         :.:.
  Rat   141 -VTSRA-QEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPQYPPTAI---------DYKC 194

  Fly   225 HLMDLDEGELFMELIRDVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPT-NKYLVAKLFD 288
            ||...:|.:.|:||::|::|:||:..|.:|||:.|.|:..|||.||||.:|... .|.||:|.||
  Rat   195 HLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFD 259

  Fly   289 VTQKTALKDAVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAIL 353
            |...|.|....|..::.|:.:|:|.||.|.|.:..:.:||.:||:|.|||.|||..|||||.::|
  Rat   260 VHAGTPLLPCSTTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLL 324

  Fly   354 CMPICNYEGDIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQIL 418
            ||||.|.:|:||||||.|||......|.|.|.::.:.||.||||.|.|||||..|.:||.|::.|
  Rat   325 CMPIRNSDGEIIGVAQAINKVPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRAL 389

  Fly   419 LNLARSIFEEQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIK 483
            |.:...:||||.:||.:|.|||..|:.|||||||||.|::           .||.|      .:|
  Rat   390 LEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLE-----------DIESP------VVK 437

  Fly   484 SADSFEEKKMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLA---QIAQFVATTGQTVNICDVI 545
            ...|||          |........|.|..:.||.:.|.|...   .||:.||:||..||:.|.
  Rat   438 FTKSFE----------LMSPKCSADAENSFKESVEKSSYSDWLINNSIAELVASTGLPVNVSDA- 491

  Fly   546 EWVRDHNQIRAEDEIDS-----TQAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFA 605
                 :...|.:.|.|.     .:::||:||.|:..::|||||::|:.:|.||.|:|..:||||.
  Rat   492 -----YQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFV 551

  Fly   606 IFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDF 670
            |||||||:||.||:...|..|||.|||:.||||||.|:.:.:|.....|.......:....|.||
  Rat   552 IFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDF 616

  Fly   671 ELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLK 735
            .|..|....|.|||||:..:|.:|:|.|:.||||:|:||||||.|.|||||||.||.|.|||||.
  Rat   617 SLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLT 681

  Fly   736 TGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTMEHHHFDQCVMILN 799
            |...:..:|::|||.::|.||||||||||||||||.|::|.||.|| |::|:|||||:..||||.
  Rat   682 TAGFQEILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSDSALAQLYGTSATLEHHHFNHAVMILQ 746

  Fly   800 SEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMM 864
            |||:|||..||.::|..:|:.::.:||:|||.:||::|..|.|||..|.:||.....:|:...|:
  Rat   747 SEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGAYDWSITSHRDVFRSML 811

  Fly   865 MTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVI 929
            |||||:.|:.||||:..:||:||..|||:|||.|:.:|...|.|:.||.||||||::|:.:||.|
  Rat   812 MTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERSELKLTPSAIFDRNRKDELPRLQLEWIDSI 876

  Fly   930 CLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEK 964
            |:|||:.|......:.|:.:....|||.|::|.:|
  Rat   877 CMPLYQALVKVNAKLKPMLDSVAANRRKWEELHQK 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	78/159 (49%)
		GAF	431..619	CDD:214500	73/195 (37%)
		PDEase_I	717..950	CDD:278654	123/233 (53%)
Pde11a	NP_543169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..125		28/107 (26%)
		GAF	217..380	CDD:214500	79/162 (49%)
		GAF	402..568	CDD:214500	74/198 (37%)
		PDEase_I	663..898	CDD:278654	123/234 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	915..935
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56763
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830