Protein Alignment Pde6 and LOC1273035

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_311976.5
• Gene: LOC1273035 / 1273035
• VectorBaseID: AGAMI1_012236
• Length: 1494
• Species: Anopheles gambiae
• Alignment Length: 1236
• Identity: 255/1236 - (20%)
• Similarity: 409/1236 - (33%)
• Gaps: 424/1236 - (34%)

  Fly    76 KLEHHHRQ---SNNNRPAVTNRSSETKLMTPTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTT 137
            :|:..||:   ..::.|....|..||...|||....||.|         |.|...|:.|  |:.|
Mosquito    34 ELKDLHRRIVLKLDDPPTNVLRLRETLARTPTVPPGSPDQ---------QYQQEGQEEL--ANCT 87

  Fly   138 ASQQD----------VDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIENRKPHKRPSVTSDL 192
            ..|:|          .|||                  .||..:  ::|..|..:
Mosquito    88 EEQEDTGLQLPVVIIADEV------------------TPPSVI--VEECAEASE----------- 121

  Fly   193 FQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFMELIR--DVANELDIDVL--CH 253
                  .|||..:....|..:|:.      |..:.|:...|   |.:|  |...||.|...  |.
Mosquito   122 ------VSPTADRGDDESGESSNQ------RNSVEDVGNVE---ESVRKLDQLEELVIAFYHSCG 171

  Fly   254 KILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIPFGIGIAGM 318
            :         .:.||      |..|.:         |...|::|..:||.|:.
Mosquito   172 R---------RSSRG------GADTEQ---------TASEAVRDGASRARAKR------------ 200

  Fly   319 VAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQIINKTNGCMEFDEH 383
             .:.:|..:..||...|                        |..|                 .:|
Mosquito   201 -TKKRQQQSSGEACTGA------------------------YHPD-----------------QQH 223

  Fly   384 ---------------DVEIFRRYLTFCGIGIQNAQLFEMSV------QEYRRNQILLNLARSIFE 427
                           |.:..|.:|........:|. .:.||      ::..:.|.|.::.....|
Mosquito   224 QKRHPDPDRTMNQGTDPDQDRDHLAHAAAAATSAP-SDTSVVPAGDGRQQAQPQPLRSIHADAPE 287

  Fly   428 EQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCE--------------ASHLEKIIE---KPN 475
            ..::|:..|.....|....|..|..|      :||.              .:..|:::|   .|.
Mosquito   288 PGHSLDRDVPLDDEEDTVTLTAETSS------ECCSQQTVVAVVAEEEEVEAQAEEVVEDGSSPG 346

  Fly   476 QPATRAI-KSADSFEEKKMRN---------------------RFTVLFE----------LGGEYQ 508
            ...|..: ..:|:..:.::.|                     |.|||.:          ||||::
Mosquito   347 HDPTETVAPGSDTTTDDEVENDDTGGSDADANDEAEPGDTCTRRTVLGQDSTPSSRRCSLGGEFE 411

  Fly   509 AANVS--RPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHN------QIRAEDEIDSTQA 565
            .....  |..:|||:::        ..|..|...:||.::.:.|::      :::.:.|......
Mosquito   412 TEQNRRLRRRLSELTNN--------FCTPKQFQQLCDNLDNITDNDLKLLVRELKRKIEFAERMN 468

  Fly   566 ILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKV 630
            .||               |.::..|.|...:            .|..|..          .|::.
Mosquito   469 WLC---------------LSSRPRGPPHRKT------------SLPKHTD----------VKKRF 496

  Fly   631 ALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQ 695
            ...|            :|...|.:..|    |....|..:|..|.|....:..||::.||:.:|.
Mosquito   497 LETC------------DKTLSDEVKAA----LRLPAFDSYEWEDWDVIHLMQTMFVELNLLEKFN 545

  Fly   696 IPYDVLCRWVLSVRKNYRPVKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDL 760
            ||...|..|:..|.|:|..|.:||:||...|||.|:.:.....:.:.:.:||:|.|||:|:||||
Mosquito   546 IPIVTLREWLYEVYKHYNDVPFHNYRHCFCVAQMMYTIAWHTNLVQRLGELEVLVLLVSCICHDL 610

  Fly   761 DHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESA 824
            ||.|.||.:|....:.||:.|. .|.:|:||......:|.....|||:.:|.|.|:.|.:.:...
Mosquito   611 DHPGYNNIYQINARTELALRYNDISPLENHHCSIAFRLLEHPECNIFRNMSKEMYKDVREGIIRC 675

  Fly   825 ILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVAD 889
            ||:||:|.:.:....|.|...  |||:..:...:|||.:::...|:|..|:|.:|.......:..
Mosquito   676 ILATDMARHNEILTQFQEATP--EFDYSNKVHTNLLCMVLIKVADISNEARPMDVAEPWVDRLLQ 738

  Fly   890 EFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPL----YE 949
            |||.|...||.: |...|....|:..|   |..||.||.::.|||:..|.:..|.:|.|    ..
Mosquito   739 EFFAQSAAEKSEGLPVTPFMDPDKVSK---PGSQVRFIGLVLLPLFEALGELLPELTDLIITPVR 800

  Fly   950 GTLENRRNWQDLAEKVEMGLTWID----------------------------------HDTIDKP 980
            ..|:..|...|.|.|....:...:                                  ..::|:|
Mosquito   801 VALDYYRRLNDAANKTRRSIAEAEAASSESGGSPQLPRSQSGISVKSRRSIPSQKSASRTSVDEP 865

  Fly   981 V-----------------EEFAACADEEIKDIEFTVTTLNCNQQSQH-----GSED---SHTPEH 1020
            :                 .|.|...|...|..:|.|.|.:.:::..|     ||.:   |...|:
Mosquito   866 ILIAAELHDLPEGSESGDSETATEVDVAEKTSKFKVDTESIHRKQSHPNSRKGSREKRPSMIGEY 930

  Fly  1021 QRSGSRLSMKKTGALGKAVRSKLSKTLYNS--------------MDGSKPKTSLKLLES------ 1065
            ..:|:|    ..|:.|. ::...::|.:.|              |....|..|:....|
Mosquito   931 YTTGTR----TRGSHGN-IQHTNNRTYFGSNRAISLDQYSNNRRMSDGVPIQSVHSDNSVLYYHH 990

  Fly  1066 ---HVSEDMD------DKS----------------------PTSPSQPQASGSMGRMSASSSTSS 1099
               |.|.|.|      |||                      |..|..|.....:|::..|||.|.
Mosquito   991 QRQHRSLDHDTMCSSSDKSTSLNSTHDTAPGGDPTTILHVPPPQPPPPTGKQRLGKLFGSSSASG 1055

  Fly  1100 A 1100
            :
Mosquito  1056 S 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	23/175 (13%)
		GAF	431..619	CDD:214500	39/244 (16%)
		PDEase_I	717..950	CDD:459723	80/238 (34%)
LOC1273035	XP_311976.5	PDEase_I	567..795	CDD:459723	79/232 (34%)