Protein Alignment Pde6 and Pde6c

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: NP_291092.1
• Gene: Pde6c / 110855
• MGIID: 105956
• Length: 861
• Species: Mus musculus
• Alignment Length: 868
• Identity: 291/868 - (33%)
• Similarity: 459/868 - (52%)
• Gaps: 81/868 - (9%)

  Fly   174 QEFIENRKPHKRPSVTSDLFQQWM--AASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGELFM 236
            ||.:| |...|.|....:.|.:.:  .|...:.:.|...:  .:..||||    :..::|..:.:
Mouse     6 QEAVE-RYLEKNPCFAKEYFDKKLRVEALGVIFKNSHAGV--QTGLSLPE----MTQVEESAVCL 63

  Fly   237 ELIRDVANEL-DIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVT 300
            ||::.:.:|. ..:.:.|:.|..:..|..||..|:|..:.......:.::|.:||..:..:|.:.
Mouse    64 ELLQCMQDEAGSAEQMAHRALQRLAQLLQADCCSMFSCRARNGIPEVASRLLNVTPTSKFEDNLV 128

  Fly   301 RASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDII 365
             |...|::.|..|||.|.||..|:.:|:.:..|::.|:..:|.:|||.|..:|.:||...: :::
Mouse   129 -APDREVVFPLDIGIVGWVAHVKKALNVSDVKKNSHFSDFMDKQTGYVTRNLLAVPIVAGK-EVL 191

  Fly   366 GVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQN 430
            .|...:||.: ..||.:.|.|:|.:||:|..:.::......:...|.||:|||:..|..:|||..
Mouse   192 AVVMAVNKIS-APEFSKQDEEVFSKYLSFVAVALRLQHTSYLYSVESRRSQILMWSANKVFEELT 255

  Fly   431 NLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRN 495
            ::|....|.:...|..|.|:|.|:.|:|:...:..:.|..|:.......:..|:.|..|
Mouse   256 DVERQFHKALYTIRTYLNCDRYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGRE------ 314

  Fly   496 RFTVLFE------LGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQI 554
               ::|.      |.|:.:...:..|.....  :.::.:..:||..|   .||:::....|....
Mouse   315 ---IIFYKIIDYILHGKEEINVIPSPPADHW--TLVSGLPTYVAENG---FICNMLNAPADEYFT 371

  Fly   555 RAEDEIDST----QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNT 615
            ..:..:|.|    :.:|.:||:|.::.::|||...|:.:|.||.:.|..|.|....|.|..:.||
Mouse   372 FQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEHITETLTQFLGWSLLNT 436

  Fly   616 QMYENACKLMAKQKVALECLSYHATASQDQ-------TEKLTQDVIAEAE--------------- 658
            ..||...||.:::.:|.|.:.....|:.|:       .|||..:||.|.|
Mouse   437 DTYERVNKLESRKDIAQEMVMNLTKATPDEISSILKFKEKLNVEVIEECEERQLLAILKEDLPDP 501

  Fly   659 -SYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNWRH 722
             :.:||.|.|:||.:.:.:..:..||:|::.|:|.:|::|.:||.||:.:|||.||||.||||||
Mouse   502 RTADLYEFCFSDFPITEHELVKCGLRLFLEINVVEKFKVPVEVLTRWMYTVRKGYRPVTYHNWRH 566

  Fly   723 ALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTME 787
            ..||.||||.:|.||:::::.||||...:|.|..|||:|||||||.:|.|:.||||.|:.||.:|
Mouse   567 GFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGTSILE 631

  Fly   788 HHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQ 852
            .||.:....:|..|..||||.|:...:.:|:...|.||::||||:|||||..|.::|:..| ..|
Mouse   632 RHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDTCE-QMQ 695

  Fly   853 GEE-----------KKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNTQP 906
            .||           ||:::..|||||||:|||.||||||.:||.|||:||::|||||:..|..||
Mouse   696 SEEETIKYVTSDPTKKEVIMAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQP 760

  Fly   907 VAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGLTW 971
            :.||||.:||||||:||||||.:|..:|:........|||:..|...||..|:.|||:.|..:
Mouse   761 IPMMDRSKKDELPKLQVGFIDFVCTFVYKEFSRFHGEITPMLNGLQNNRVEWKSLAEEYEAKV-- 823

  Fly   972 IDHDTIDKPVEEFAACADEEIKD 994
                   |..||.|...:||..|
Mouse   824 -------KVTEEEAGKQEEEASD 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	43/158 (27%)
		GAF	431..619	CDD:214500	44/197 (22%)
		PDEase_I	717..950	CDD:278654	123/243 (51%)
Pde6c	NP_291092.1	GAF	81..232	CDD:214500	43/153 (28%)
		GAF	256..443	CDD:214500	46/200 (23%)
		PDEase_I	561..806	CDD:278654	124/245 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	826..861		6/14 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56437
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930