DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and pde1ca

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_021326050.1	Gene:	pde1ca / 101883995	ZFINID:	ZDB-GENE-111215-4	Length:	777	Species:	Danio rerio

Alignment Length:	682	Identity:	164/682 - (24%)
Similarity:	279/682 - (40%)	Gaps:	153/682 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 IKSADSFEEKKMRNRFTV-LFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVI 545
            :.|.|:.|:..:|.|..| ..|.|   :|:.|......|.::|.|..:  ::..|.:.|:
Zfish    91 VDSPDAMEKTAIRLRCLVKQLERG---EASVVDLKKNLEYAASVLESV--YIEETRRLVD----- 145

  Fly   546 EWVRDHNQIRAEDEIDSTQAILCMP------IMNAQKKVIGVAQLINKANGVPFTDSDASIFEAF 604
                      .|||:...|:. .:|      :.:...:.:|:  ::.::...|...|.....:|
Zfish   146 ----------TEDELSDIQSD-SVPSEVRDWLASTFTRQMGL--MLRRSEEKPRFRSIVHAVQA- 196

  Fly   605 AIFCGLGIHNTQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSF-TFT 668
                  ||...:||.....::.        |||            ...||...:..:.:|| .||
Zfish   197 ------GIFVERMYRRTSNMVG--------LSY------------PPSVITALKHVDTWSFDVFT 235

  Fly   669 DFELVDDDTCRAVL-RMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTM 730
            ..:...|.:.:.:. .:..:.:|:::|:||...|..:|.::...|...:  |||..||.:|.||:
Zfish   236 LNDASGDHSLKFIFYELLTRYDLINRFKIPVSALVSFVEALEVGYGKHRNPYHNLIHAADVTQTV 300

  Fly   731 -FAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQ 793
             :.:|||| |..::|:|||..:|.|...||.:|.||.|.|..:|.|..||||. .:..|:||...
Zfish   301 HYLLLKTG-MVHWLTELEIFAMLFAAAVHDYEHTGTTNNFHIQTRSDTAILYNDRAVQENHHVSA 364

  Fly   794 CVMILNSEGN-NIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKK 857
            ...:|..:.. ||...||.:|:|.:...|...:|:||::.:|::..|....::..|    |.:|.
Zfish   365 AYRLLQEDDEMNILYNLSKDDWRELRTLVVEMVLATDMSCHFQQIKAMKNFLQQPE----GIDKP 425

  Fly   858 DLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDEL-PK 920
            ..|..::.|| |:|..||.|.:.::....:.:|||.|||.| :|.|...|:.    :||..: .:
Zfish   426 KALSLLLHTA-DISHPAKNWNMHYRWTTSLLEEFFRQGDKEAELGLPFSPLC----DRKSTMVAQ 485

  Fly   921 MQVGFIDVICLPLYRVLCDTFPWI-TPLYE------------GTLEN----------RRNWQDLA 962
            .|:||||.|..|.:.||.|....| |||.|            .:|.|          |....:..
Zfish   486 SQIGFIDFIVEPTFTVLTDMIEKIMTPLIEEASPAGLAGFRRSSLNNIPSDGKRSSVRSTGSEGG 550

  Fly   963 EKVEMGLTWIDHDT--------IDKPVEEFAACA----DEEIKDIEFTVTTLNCNQQSQHGSEDS 1015
            ..|...:..:|..|        :.|..|::.|.|    :|:.|..|........:..:|...:::
Zfish   551 TSVNSSINAVDFKTFKSTWNEEVHKNREKWKAQAAKDLEEKAKQEEMEENEKKKDTDTQSSDDNT 615

  Fly  1016 HT------------PEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTSLKLLESHVS 1068
            .|            |:.|:..:|             ..|.|||  :..|..|.|
Zfish   616 KTEDKINTDSNAKSPDKQKEDTR-------------PEKDSKT--DQEDSGKAK----------- 654

  Fly  1069 EDMDDKSPT--SPSQPQASGSMGRMSASSSTS 1098
              :|:|.||  .|.:.:.:...|.|:.:.:.|
Zfish   655 --VDNKEPTEQQPREKEGNKDPGGMNGAQTPS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	27/143 (19%)
		PDEase_I	717..950	CDD:278654	86/250 (34%)
pde1ca	XP_021326050.1	PDEase_I_N	146..202	CDD:312112	11/65 (17%)
		PDEase_I	287..513	CDD:306695	83/235 (35%)
		COG3942	584..>760	CDD:332523	24/129 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010