Protein Alignment Pde6 and pde4d

DIOPT Version :10

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_031749923.1
• Gene: pde4d / 100496479
• XenbaseID: XB-GENE-1013100
• Length: 912
• Species: Xenopus tropicalis
• Alignment Length: 1102
• Identity: 238/1102 - (21%)
• Similarity: 401/1102 - (36%)
• Gaps: 312/1102 - (28%)

  Fly    37 TNGANKTAISTAAGGVTPGAVPGPGSGAIPASSSSGNQVKLEHHHRQSNNNR---PAVTNRSSET 98
            |.|:..:|:..::...:        :|:..:|||:||....:|..||....|   ||:.:..|..
 Frog     3 TEGSKLSALLNSSSNCS--------NGSSDSSSSTGNLKAPKHLWRQEQQQRWQCPALHHHQSFV 59

  Fly    99 KLMTPTGSSSSPSQSPSQTQASIQTQTSQQDRLAKASTTASQQDVD------EVARLFEEKPEAF 157
            :...|          |:....:          |.......|||::.      .:|::........
 Frog    60 QHQEP----------PAPLHPA----------LPDTPLLLSQQNIYPLLHPLPLAQINPALQPQI 104

  Fly   158 EKWLTERAPPEALSRLQEFI-------------ENRKPHKRPSVTSDLFQQWMA-ASPTVQQKSP 208
            ...|..:..|:.|..||..|             ....|..:|.:..||..|..: .:|.:|.:||
 Frog   105 YSVLPSQPAPQILPALQAHIYPVHQPQSPALSPSQVSPGLQPQIYPDLQPQPSSQINPALQPQSP 169

  Fly   209 RSLS---------------NSSASSLPECR-------------RHLMDLDEGELFMELIRDVANE 245
            ..:.               :|.|...|.|.             || ....:.|.::.
 Frog   170 PQIQAQPHPLLPFQLQPQLHSQAQPAPHCPPVSSRTRYSNSRVRH-RGFSDTERYLH-------- 225

  Fly   246 LDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAEEIIIP 310
                  |..:..:...:....|..|..::.:..:.:...:.|||...|        .|....:.|
 Frog   226 ------CQAMDRSSYAVDTGHRPGLKKSRMSWPSSFQGFRRFDVDNGT--------TSGRSPLDP 276

  Fly   311 FGIGIAGMVAQTKQMINIKEAYKDARF------NCEIDLKTGYKTNAILCMPICNYEGDIIGVAQ 369
            .....:|::.|.    |...:.:...|      :.|:..|:..:.::|        ..||.|
 Frog   277 MTSPGSGLILQA----NFVHSQRRESFLYRSDSDYELSPKSMSRNSSI--------ASDIHG--- 326

  Fly   370 IINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRN-QILLNL------ARSIFE 427
                       |:..|..|.:.|.              |::..|.| ..|.||      .||...
 Frog   327 -----------DDLIVTPFAQVLA--------------SLRTVRNNFAALTNLQDRAPSKRSTMC 366

  Fly   428 EQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATR-AIKSADSFEEK 491
            .|.::.  ...|..||.:.|..|.    |.:||.| ...||.:       .|| ::....|.:.|
 Frog   367 NQPSIN--KATIPEEAYQKLAGET----LEELDWC-LDQLETL-------QTRHSVSEMASNKFK 417

  Fly   492 KMRNRFTVLFELGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRA 556
            :|.||     ||           ..:||:|.|. .|::::::.|     ..|     :.|
 Frog   418 RMLNR-----EL-----------THLSEMSRSG-NQVSEYISNT-----FLD-----KQH----- 450

  Fly   557 EDEIDSTQAILCMPIMNAQKK-------VIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHN 614
            |.|:.|       |....::|       :.||.:|::.::   .|:|:...|         |:.:
 Frog   451 EVEMPS-------PAQKEKEKKKRPMSQISGVKKLMHSSS---LTNSNIPRF---------GVKS 496

  Fly   615 TQMYENACKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCR 679
                ||.           |||:           |..:||    ..:.|..|...:|.  .:....
 Frog   497 ----ENE-----------ECLA-----------KELEDV----NKWGLNIFKVAEFS--GNRPLT 529

  Fly   680 AVLR-MFMQCNLVSQFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERF 742
            .|:. :|.:..::..|:||.|.|..:::::..:|. .|.|||..||.:|||:...:|.:..:|..
 Frog   530 VVMHTIFQEREMLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVAQSTHVLLSSPALEAV 594

  Fly   743 MTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIF 806
            .||||||..:.|...||:||.|.:|.|...|.|.||::|. :|.:|:||......:|..|..:||
 Frog   595 FTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIF 659

  Fly   807 QALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMM 864
            |.|:.:..:.:.|.|...:|:||::.:.........:||..:....|       .::..:|..|:
 Frog   660 QNLTKKQRQLLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMV 724

  Fly   865 MTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDV 928
            ..| |:|...||..:.......:.:|||.|||.|:.: :...|  |.|:... .:.|.||||||.
 Frog   725 HCA-DLSNPTKPLPLYRHWTDRIMEEFFRQGDRERERGMEISP--MCDKHNA-SVEKSQVGFIDY 785

  Fly   929 ICLPLYRVLCD-TFPWITPLYEGTLENRRNW--------------------QDLAEKVEMGLTWI 972
            |..||:....| ..|....:.: |||:.|.|                    |...||.:..||..
 Frog   786 IVHPLWETWADLVHPDAQDILD-TLEDNREWYQSTIPQSPSPAPDEQEEGKQGQTEKFQFELTLE 849

  Fly   973 DHDTID------KPVEEFAACADEE---IKDIEFTVTTLN---CNQQSQ---HGSEDSHTPE 1019
            :....|      ..|||..:|:|.:   .:|.|.|...|:   ..::||   :..|.:|:|:
 Frog   850 EDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDDQVDEEESQLEPNSIEQAHSPD 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	23/164 (14%)
		GAF	431..619	CDD:214500	40/195 (21%)
		PDEase_I	717..950	CDD:459723	76/242 (31%)
pde4d	XP_031749923.1	Atrophin-1	<76..>199	CDD:460830	22/122 (18%)
		PDE4_UCR	331..447	CDD:465648	38/165 (23%)
		PDEase_I	569..809	CDD:459723	76/244 (31%)