DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde1c

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_031759760.1	Gene:	pde1c / 100495383	XenbaseID:	XB-GENE-994226	Length:	762	Species:	Xenopus tropicalis

Alignment Length:	567	Identity:	140/567 - (24%)
Similarity:	218/567 - (38%)	Gaps:	139/567 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   611 GIHNTQMYENACKLMAKQKVALECLSY--HATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELV 673
            ||...:||.....::.        |||  ...|.....:|.:.||.|..::...:...|..:||:
Frog   195 GIFVERMYRRTSNMVG--------LSYPPAVIAVLKNVDKWSFDVFALNDASGDHGLKFIFYELL 251

  Fly   674 DDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK--YHNWRHALNVAQTMFAMLKT 736
                        .:.:|:::|:||...|..:|.::...|...|  |||..||.:|.||:...|..
Frog   252 ------------TRYDLINRFKIPISALVSFVEALEVGYTKHKNPYHNLIHAADVTQTVHYFLFK 304

  Fly   737 GKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMIL-N 799
            ..:..::|:|||..::.|...||.:|.||.|.|..:|.|..||||. .|.:|:||......:| :
Frog   305 SGLVHWLTELEIFAMIFAAAVHDYEHTGTTNNFHIQTRSDSAILYNDRSVLENHHVSAAYRLLQD 369

  Fly   800 SEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMM 864
            .|..||...||.:|:|.....|...:|:||::.:|.:    ::.::|.....:|.:|...|..::
Frog   370 DEEMNILYNLSKDDWREFRALVIEMVLATDMSCHFHQ----IKQMKNALQQPEGIDKPKALSLLL 430

  Fly   865 MTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDELPKMQVGFIDV 928
            .|| |:|..||.|::.|:....:.:|||.|||.| :|.|...|  :.|| ....:.:.|:||||.
Frog   431 HTA-DISHPAKNWDLHHRWTMSLLEEFFRQGDKEAELGLPFSP--LCDR-NSTMVAQSQIGFIDF 491

  Fly   929 ICLPLYRVLCDTFPWI-TPL--------------------------------------------- 947
            |..|.:.||.|....| .||
Frog   492 IVEPTFTVLTDMIEKIVVPLIEEASRSGLTGFRRSSLNSITTSDVKRSSVKSTGSEGSASLNCSI 556

  Fly   948 ------------YEGTLENRRNWQDLAEKVEMGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVT 1000
                        |:..|:||..|:..|.|          |..:|...|    |:|:.|
Frog   557 LTVDFKSFKCTWYDVVLQNREKWKTQAVK----------DADEKAKRE----AEEKDK------- 600

  Fly  1001 TLNCNQQSQHGSEDSHTPEHQRSGSRLSMKKTGALGKAVRSKLSKTLYNSMDGSKPKTS--LKLL 1063
              ....::....||..|.|::                   .|..|.|.|..:.:|...|  .||.
Frog   601 --RDPDENHQEKEDKKTDENE-------------------DKNDKPLLNKHEPNKEHHSGDSKLT 644

  Fly  1064 ESHVSEDMDDKSPTSPSQPQASGSMGRMSASSSTSSAGGQMVDKSKK 1110
            ||........:.|.:.:|..:||..........|.|.  |:|....|
Frog   645 ESSQGNINGTRLPNAKNQECSSGDQTNQEKLGDTDSK--QVVQNGIK 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	3/7 (43%)
		PDEase_I	717..950	CDD:278654	82/293 (28%)
pde1c	XP_031759760.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010