Protein Alignment Pde6 and pde4a

DIOPT Version :9

• Sequence 1: NP_001262566.1
• Gene: Pde6 / 41760
• FlyBaseID: FBgn0038237
• Length: 1124
• Species: Drosophila melanogaster
• Sequence 2: XP_031755243.1
• Gene: pde4a / 100488846
• XenbaseID: XB-GENE-5789473
• Length: 744
• Species: Xenopus tropicalis
• Alignment Length: 629
• Identity: 148/629 - (23%)
• Similarity: 253/629 - (40%)
• Gaps: 141/629 - (22%)

  Fly   465 SHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFTVLFELGGEYQAANVSRPS------------- 516
            :|.|.:|..|......:::|        :||.||:|         |||:.|:
 Frog   159 AHAEDLIVTPFAQVLASLRS--------VRNNFTIL---------ANVTTPTNKRSPVMPQQTVC 206

  Fly   517 VSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDHNQIRAEDEIDSTQAILCMPIMNAQK----- 576
            .:.||..|..|:|:      :|:   :.::|        ..|::::.|....:..|.:.|
 Frog   207 KATLSEETYQQLAK------ETL---EELDW--------CLDQLETMQTYRSVSEMASNKFKRML 254

  Fly   577 --KVIGVAQLINKANGV------PFTDSDASIFEAFAIFCGLGIHNTQMYEN--------ACKLM 625
              ::..::::....|.|      .|.|....:          .|.:....|.        .|::.
 Frog   255 NRELTHLSEMSRSGNQVSEYISNTFLDKQNEV----------DIPSPTQKEREKKKKQQPMCQIS 309

  Fly   626 AKQKVALECLSYHATA-----------SQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCR 679
            ..:|:      .|:::           ..||.|.|.:: :.....:.|..|...::......:|
 Frog   310 GVKKL------MHSSSLTNSAIPRFGVKTDQEESLGKE-LDNLNKWGLNIFRVAEYSNNRPLSC- 366

  Fly   680 AVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYR-PVKYHNWRHALNVAQTMFAMLKTGKMERFM 743
            .:..:|.:..|:..|:||.|.|..:::::..:|. .|.|||..||.:|.|:...:|.|..::...
 Frog   367 TMYTVFQERELLKTFKIPVDTLMTYMMTLEDHYHADVAYHNSLHAADVTQSTHVLLSTPALDAVF 431

  Fly   744 TDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYT-TSTMEHHHFDQCVMILNSEGNNIFQ 807
            ||||||..|.|...||:||.|.:|.|...|.|.||::|. .|.:|:||......:|..|..:|||
 Frog   432 TDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQ 496

  Fly   808 ALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQG-------EEKKDLLCGMMM 865
            .|:....:::.|.|...:|:||::.:.........:||..:....|       .::..:|..|:.
 Frog   497 NLTKRQRQTMRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVH 561

  Fly   866 TACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQ-LNTQPVAMMDRERKDELPKMQVGFIDVI 929
            .| |:|...||.|:..:....:.:|||.|||.|:.: :...|  |.|:... .:.|.||||||.|
 Frog   562 CA-DLSNPTKPLELYRQWTDRILEEFFRQGDKERERGMEISP--MCDKHTA-SVEKSQVGFIDYI 622

  Fly   930 CLPLYRVLCD-TFPWITPLYEGTLENRRNW--------------------QDLAEKVEMGLTW-- 971
            ..||:....| ..|....:.: |||:.|:|                    :...||.:..||.
 Frog   623 VHPLWETWADLVHPDAQDILD-TLEDNRDWYQGMIPQSPSPPPDDPDKDEEACIEKFQFELTLEE 686

  Fly   972 ----IDHDTIDKPVEEFAACADE--EIKDIEFTVTTLNCNQQSQ 1009
                .|.|......||...|..|  ||::.|....|::..|..|
 Frog   687 EAEDSDKDRNSGIEEEDGNCLHEAPEIQEPEEEFMTMHEGQAEQ 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	30/179 (17%)
		PDEase_I	717..950	CDD:278654	77/242 (32%)
pde4a	XP_031755243.1	PDE4_UCR	166..281	CDD:407935	25/148 (17%)
		PDEase_I	405..646	CDD:395177	78/245 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010