DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde6c

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_002937230.1	Gene:	pde6c / 100485634	XenbaseID:	XB-GENE-487059	Length:	853	Species:	Xenopus tropicalis

Alignment Length:	859	Identity:	282/859 - (32%)
Similarity:	458/859 - (53%)	Gaps:	83/859 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 LQEFIENRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPE--CRRHLMDLDEGELF 235
            :::::||     .|....:.|.:      .::.::..:|.||....|.:  ..|.:..::|.::.
Frog     9 IEKYLEN-----NPQFAKEYFDK------KLRSETVGALFNSKELVLKDGVSFREMTKIEEADIL 62

  Fly   236 MELIRDVANELDIDVLCHKILVNVGLLTHADRGSLF---LAKGTPTNKYLVAKLFDVTQKTALKD 297
            :|||:::.::.:::...||:|..:..|..||..|:|   ...|.|.   |..:||:||:.:..:|
Frog    63 LELIKEIQDDCNMEKTVHKVLQRMAYLLQADCCSMFGFRSRNGIPE---LATRLFNVTKSSKFED 124

  Fly   298 AVTRASAEEIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEG 362
            .:. |...||:.|..|||.|.||.||:..|:.:..|:..|:...|.:|||.|..:|..||...:
Frog   125 NLV-APESEIVFPLDIGIVGWVAHTKKSFNVPDVKKNTHFSDFADKQTGYTTKNLLAAPILQGK- 187

  Fly   363 DIIGVAQIINKTNGCMEFDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFE 427
            :::.|...:||.|.. ||.:.|.|:|.:||.|..:.::...:..:...|.|::|:||..|..:||
Frog   188 EVLAVMMAVNKQNAA-EFSKEDEEVFHKYLNFISVVLKYNHINYLHNIETRKSQVLLWTANKVFE 251

  Fly   428 EQNNLECLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKK 492
            |..::|....|.:...|..|.|||.||.|:|:...:..:.|..|:....|..:..|:.|..|
Frog   252 ELTDIERQFHKALYTVRVYLNCERYSVGLLDMTKEKEFYEEWPIKLGEVPPYKGPKTPDGRE--- 313

  Fly   493 MRNRFTVLFE------LGGEYQAANVSRPSVSELSSSTLAQIAQFVATTGQTVNICDVIEWVRDH 551
                  |:|.      |.|:.:...:  |:..|...|.::.:..:||..|   .||:::....|.
Frog   314 ------VIFYKIIDYILHGKEEIKVI--PTPPEDHWSLVSGLPTYVAENG---FICNMMNAPADE 367

  Fly   552 NQIRAEDEIDST----QAILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGI 612
            .....::.:|.|    :.:|.:||:|.:::::|||...|:.:..||.:.|..|.||.....|..:
Frog   368 FFKFQKEAVDETGWTIKNVLSLPIVNKKEEIVGVATFYNRKDAKPFDEYDEQITEALTQILGWSV 432

  Fly   613 HNTQMYENACKLMAKQKVALECLSYH--ATASQDQT-----EKLTQDV---------------IA 655
            .||..|:...||..::.:|.|.|.|.  .|..:.|:     |||.::|               :.
Frog   433 LNTDTYDKMNKLENRKDIAQEMLMYQLKCTPKELQSILKTKEKLNKEVEECEETELLKILKEELP 497

  Fly   656 EAESYNLYSFTFTDFELVDDDTCRAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVKYHNW 720
            :..:..||.|.|:|..:.:.|..::.:|:|.:.|.|.:|::|.:||.:|:.:|||.||.:.||||
Frog   498 DPITAELYEFHFSDLPVSEHDLIKSGIRLFFEINAVDKFKVPVEVLTKWMYTVRKGYRDITYHNW 562

  Fly   721 RHALNVAQTMFAMLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILYTTST 785
            ||..||.||||.:|.|||::::.:|||...::.|..|||:|||||||.:|.|:::|||.|:.:|.
Frog   563 RHGFNVGQTMFTLLMTGKLKKYYSDLEAFAMVAAAFCHDIDHRGTNNLYQMKSQAPLAKLHGSSI 627

  Fly   786 MEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFD 850
            :|.||.:....:|..|..||||.|:...:.:|:...|.||::||||:|||||..|.::|:..| .
Frog   628 LERHHLEFSKTLLQDESINIFQTLNKRQFENVIHLFEVAIIATDLALYFKKRTMFQKIVDTTE-Q 691

  Fly   851 WQGEE-----------KKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLEKLQLNT 904
            .|.|:           ||:::..||||.||:|||.||||||.|||.:||:||::|||||:..|..
Frog   692 MQSEDERIKYIICDPTKKEIIMAMMMTGCDLSAITKPWEVQSKVALMVANEFWEQGDLERTVLQQ 756

  Fly   905 QPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVEMGL 969
            ||:.||||.:.|||||:||||||.:|..:|:........|.|:|:|...||..|:..|:..|..:
Frog   757 QPIPMMDRNKSDELPKLQVGFIDFVCTFVYKEFSRFHKEILPMYDGLQNNRVQWKSQADVYEEKM 821

  Fly   970 TWIDHDTIDKPVEE 983
            ..:|.   .|..||
Frog   822 KILDE---QKKKEE 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	51/161 (32%)
		GAF	431..619	CDD:214500	49/197 (25%)
		PDEase_I	717..950	CDD:278654	117/243 (48%)
pde6c	XP_002937230.1	GAF	74..223	CDD:214500	51/154 (33%)
		GAF	255..442	CDD:214500	50/200 (25%)
		PDEase_I	559..804	CDD:365964	118/245 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11347
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.110