DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde5aa

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_009305135.1	Gene:	pde5aa / 100334568	ZFINID:	ZDB-GENE-100414-2	Length:	922	Species:	Danio rerio

Alignment Length:	993	Identity:	295/993 - (29%)
Similarity:	476/993 - (47%)	Gaps:	140/993 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GAASPVEMSTTSSSSAATTSASSSKPLTNGAN-----KTAISTAAGGVTPGAVPGPGSGAIP-AS 68
            |.||....|..|.|.:.....|..|......|     :.||::||...||..|||..:..:. ..
Zfish    19 GVASSRRGSQGSRSKSGKKRKSGEKSTRVERNEIEKEQCAITSAAWFFTPLWVPGAKTQRLGFRM 83

  Fly    69 SSSGNQVKL----------EHHHRQSNN--NRPAVTNRSSETKLMTPTGSS--------SSPSQS 113
            .....:||.          .:..|.|.|  |..|...::::|.:..|...:        |.|...
Zfish    84 GKESEKVKAWLDDYSDSARSYFSRSSRNWMNGCAERAQAAQTLITEPRSKTTVLGRRRVSHPMSG 148

  Fly   114 PSQTQASIQTQTSQQDRLAKASTTASQQDVDEVARLFEEKPEAFEKWLTERAPPEALSRLQEFIE 178
            ||:......|....|..|: ...|...:.:|:....|   |.:.:......:|..:.||...|:.
Zfish   149 PSRALVHPVTMQRPQSCLS-VHQTDHPESLDQGGGHF---PRSLQPIHFTFSPCRSRSRCSSFLG 209

  Fly   179 NRKPHKRPSVTSDLFQQWMAASPTVQQKSPRSLSNSSASSLPECRRHLMDLDEGE---LFMELIR 240
            :.:|                                    ..:|||       ||   ..|:|..
Zfish   210 SPRP------------------------------------AGQCRR-------GESCAFMMQLFS 231

  Fly   241 DVANELDIDVLCHKILVNVGLLTHADRGSLFLAKGTPTNKYLVAKLFDVTQKTALKDAVTRASAE 305
            .:...|....|..::|.::..:|.|.|.||.:.....|....:..:......:...:|.|:
Zfish   232 GLIGALQDKNLHLQVLQHLCEVTEAQRVSLSMTTVDKTGGKCLGPVLQSDADSVHSNAQTK---- 292

  Fly   306 EIIIPFGIGIAGMVAQTKQMINIKEAYKDARFNCEIDLKTGYKTNAILCMPICNYEGDIIGVAQI 370
                 :...|...|.:|.:.:.:|:|::|.||..|:......:..::|.:|:.|::.::|||...
Zfish   293 -----WNKSIMEYVVRTGRPLTVKDAHEDPRFQVELYEGEEDRPTSVLSVPVLNHKKEVIGVVLA 352

  Fly   371 INKTNGCME--FDEHDVEIFRRYLTFCGIGIQNAQLFEMSVQEYRRNQILLNLARSIFEEQNNLE 433
            :|||..|..  |.|.|.::...::...|:.::|.||.|.|.||.:|||:||.||:.:..:..:::
Zfish   353 VNKTRTCASSFFSEQDEKVLSSHMMLFGLILENHQLCESSEQENKRNQVLLELAQLVSHDYPSVD 417

  Fly   434 CLVTKIMTEARELLKCERCSVFLVDLDCCEASHLEKIIEKPNQPATRAIKSADSFEEKKMRNRFT 498
            .::.::......:.|.:.|:||:.|                 ..:||.               |:
Zfish   418 AMLGELAAVILPITKAQFCTVFISD-----------------DSSTRL---------------FS 450

  Fly   499 VLFELGGEYQAANVS-RPSVSELSSSTLAQI-AQFVATTGQTVNICDVIEWVRDHNQIRAEDEID 561
            .:..:  ||:....| ..|..:..:..::.| |..|..:.:|:||.:           |....:.
Zfish   451 RMVRI--EYEEIECSVHCSSRDCDTDDVSYIYAMHVQNSMETLNIVN-----------RPISMVS 502

  Fly   562 STQAILCMPIMNAQ-KKVIGVAQLINK----ANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENA 621
            ..::::..|:...| ..||||.||:||    |....|:.:|..:.|.||::|.||:......:.|
Zfish   503 PIRSLIGAPLRGKQSSNVIGVCQLVNKRMAIAESEAFSRADEHLLEDFAVYCALGLQKFNTQQTA 567

  Fly   622 CKLMAKQKVALECLSYHATASQDQTEKLTQDVIAEAESYNLYSFTFTDFELVDDDTCRAVLRMFM 686
            .|...:..|..|.|||..:|||::..:|.:..|..|::.:|..|.|:||::..:...:||:|||:
Zfish   568 DKTRVRLAVTKEVLSYQISASQEEINELEEAAIPSADTLSLLDFGFSDFDMSQNAMTQAVVRMFL 632

  Fly   687 QCNLVSQFQIPYDVLCRWVLSVRKNYRP-VKYHNWRHALNVAQTMFAMLKTGKMERFMTDLEILG 750
            ..||..:|:|.|..||:|||||:|.||. |.||||.|||..||.|||||:|.:::..::.||:|.
Zfish   633 DLNLPQEFKIDYKALCQWVLSVQKCYRSNVVYHNWSHALRTAQCMFAMLQTKELKSNLSSLEVLA 697

  Fly   751 LLVACLCHDLDHRGTNNAFQTKTESPLAILYTTSTMEHHHFDQCVMILNSEGNNIFQALSPEDYR 815
            |::|.|.|||||||.||::..::..|||.||..|::||||:|.|::|||:.|:.|..:||..:|.
Zfish   698 LMIASLSHDLDHRGVNNSYIQRSNQPLAQLYGQSSLEHHHYDMCLLILNNPGSQILSSLSVNEYM 762

  Fly   816 SVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQ 880
            :.::.:|..||:||||::|:||..|.:|.||....|:.|..::||..|:|||.|:.||.|||.||
Zfish   763 ACLQMIEKNILATDLAIFFEKRTKFFKLAENNSCLWKDEGHRELLRSMLMTASDICAITKPWPVQ 827

  Fly   881 HKVAKLVADEFFDQGDLEKLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLYRVLCDTFPWIT 945
            .::|:|||.||:.|||.||.:||.||:.:||||....||:|||.:||.||.|||..|.......:
Zfish   828 KRIAELVATEFYAQGDREKRELNIQPIDVMDRENASRLPQMQVDYIDGICSPLYEALAFICESCS 892

  Fly   946 PLYEGTLENRRNWQDLAE 963
            ||.||..:||::||::.:
Zfish   893 PLKEGCSKNRKHWQEMVD 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500	36/160 (23%)
		GAF	431..619	CDD:214500	38/194 (20%)
		PDEase_I	717..950	CDD:278654	114/232 (49%)
pde5aa	XP_009305135.1	GAF	245..388	CDD:214500	33/151 (22%)
		GAF	415..558	CDD:307634	37/187 (20%)
		PDEase_I	664..894	CDD:306695	112/229 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920