DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde6 and pde7a

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_005162725.1	Gene:	pde7a / 100151215	ZFINID:	ZDB-GENE-031222-10	Length:	516	Species:	Danio rerio

Alignment Length:	451	Identity:	109/451 - (24%)
Similarity:	191/451 - (42%)	Gaps:	75/451 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   514 RPSVSELSSSTLAQIAQFVATTGQTV--------NICDVIEW-----VRDHNQIRAEDEIDSTQA 565
            |.::|..||...|...:.:|.|.:|:        ..|.:.:.     ||..:|:..|.|...:..
Zfish    48 RGAISYDSSDQTALYIRMLAVTNKTIKSSFVFTPGACVIFKQLFSRDVRVRSQVGFEPERRGSHP 112

  Fly   566 ILCMPIMNAQKKVIGVAQLINKANGVPFTDSDASIFEAFAIFCGLGIHNTQMYENACKLMAKQKV 630
            .|                      |:.|..                :|:..  |:|..:.|::..
Zfish   113 YL----------------------GIDFRT----------------LHSRA--ESAGSIPARRIR 137

  Fly   631 ALECLSYHATASQ--------DQTEKLTQDVIAEA----ESYNLYSFTFTDFELVDDDTCRAVL- 682
            .|.....|..:|:        :....|.:|...:|    |....::|....|:.:.:......|
Zfish   138 RLFSFQRHLLSSRLLRGAPHLNPLHILDEDYCGQAKCMLEKVGSWNFDIFLFDRLTNGNSLVFLT 202

  Fly   683 -RMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPVK-YHNWRHALNVAQTMFAMLKTGKMERFMTD 745
             .:..|..|:..||:....:.|:::.|:::|.... |||..||.:|.|.|...|:..|:.:.:|.
Zfish   203 FHLLSQYGLIELFQLDMVKVRRFLVLVQEDYHNQNPYHNAVHAADVTQAMHCYLREPKLAQSLTS 267

  Fly   746 LEILGLLVACLCHDLDHRGTNNAFQTKTESPLAILY-TTSTMEHHHFDQCVMILNSEGNNIFQAL 809
            .:||..|:|...|||||.|.|..|..||...||.|| .||.:|:||:...|.:|..  ..:|..|
Zfish   268 FDILLGLLAAATHDLDHPGVNQPFLIKTNHYLAALYRNTSVLENHHWRSAVGLLRE--TELFSHL 330

  Fly   810 SPEDYRSVMKTVESAILSTDLAMYFKKRNAFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIA 874
            ..||..|:.:.:.|.||:||::...:..:.|...::..:.:......:..:..|.:...|:....
Zfish   331 PAEDSLSIERQLGSLILATDISRQNEYLSRFRTHLDENDLNLGNASHRHFVLQMALKCADICNPC 395

  Fly   875 KPWEVQHKVAKLVADEFFDQGDLE-KLQLNTQPVAMMDRERKDELPKMQVGFIDVICLPLY 934
            :|||:..:.::.|.:|||.|||:| ||:|...|  :.|.| .:.:..:|:||:..:..||:
Zfish   396 RPWELSKQWSEKVTEEFFHQGDIEKKLKLEISP--LCDSE-ANTIASVQIGFMTYVVEPLF 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500	18/117 (15%)
		PDEase_I	717..950	CDD:278654	71/220 (32%)
pde7a	XP_005162725.1	PDEase_I	239..459	CDD:278654	71/220 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920