DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde6 and pde1b

DIOPT Version :9

Sequence 1:	NP_001262566.1	Gene:	Pde6 / 41760	FlyBaseID:	FBgn0038237	Length:	1124	Species:	Drosophila melanogaster
Sequence 2:	XP_017946519.1	Gene:	pde1b / 100036722	XenbaseID:	XB-GENE-987197	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	433	Identity:	113/433 - (26%)
Similarity:	187/433 - (43%)	Gaps:	70/433 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   653 VIAEAESYNLYSFTFTDFELVDDDTC--RAVLRMFMQCNLVSQFQIPYDVLCRWVLSVRKNYRPV 715
            |:...:..:|:.|.......|.:|..  ..|..:..:.||.|:|:||...|..::.|:...|...
Frog   172 VVNSLKHLDLWDFDVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMSFLDSLESGYGKY 236

  Fly   716 K--YHNWRHALNVAQTMFA-MLKTGKMERFMTDLEILGLLVACLCHDLDHRGTNNAFQTKTESPL 777
            |  |||..||.:|.||:.. :|:|| |...:.::|||.::.|...||.:|.||.|:|..:|:|..
Frog   237 KNPYHNQIHAADVTQTVHCFLLRTG-MVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKSDC 300

  Fly   778 AILYT-TSTMEHHHFDQCVMILNSEGNNIFQALSPEDYRSVMKTVESAILSTDLAMYF---KKRN 838
            ||||. .|.:|:||......|:..:..|||..|:.:::..:...|...:|:||::.:|   |...
Frog   301 AILYNDRSVLENHHVSAVYRIMQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKTMK 365

  Fly   839 AFLELVENGEFDWQGEEKKDLLCGMMMTACDVSAIAKPWEVQHKVAKLVADEFFDQGDLE-KLQL 902
            ..|:.:|..:        |.....:::.|.|:|...|.|:|..:..|.:.:|||.|||.| ::.|
Frog   366 TSLQQLETID--------KSKALSLLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKEAEMGL 422

  Fly   903 NTQPVAMMDRERKDEL-PKMQVGFIDVICLPLYRVLCDTFPWITPLYEGTLENRRNWQDLAEKVE 966
            ...|:.    :||..| .:.|:|||:.|..|.:.||                     .|:|||..
Frog   423 PFSPLC----DRKSTLVAQSQIGFIEFIVDPTFSVL---------------------TDVAEKTV 462

  Fly   967 MGLTWIDHDTIDKPVEEFAACADEEIKDIEFTVTTLNCNQQSQHGSEDSHTPEHQRSGSRLSMKK 1031
            :.|.                   ||....:.|.:....:.|.:..|.|.|:.....:....|.:.
Frog   463 LPLV-------------------EERSKSKSTASVNQSSSQWRQPSIDDHSEMGDINADIKSFRT 508

  Fly  1032 TGALGKAVRSKLSKTLYNSMDGSKPKTSLKLL----ESHVSED 1070
            |..  |.::....|....:..|...:||:..|    |.|.:|:
Frog   509 TWT--KYIQENKQKWKERAASGITNQTSVDELSPCEEQHSTEE 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde6	NP_001262566.1	GAF	247..406	CDD:214500
		GAF	431..619	CDD:214500
		PDEase_I	717..950	CDD:278654	74/239 (31%)
pde1b	XP_017946519.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010