DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001003947.1	Gene:	Cyp4x1 / 81906	MGIID:	1932403	Length:	507	Species:	Mus musculus

Alignment Length:	475	Identity:	125/475 - (26%)
Similarity:	209/475 - (44%)	Gaps:	68/475 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RRRLYFLMLKIPGPIGLPILG----------SSLENIITYKRKLSFRTKYLNKYGSTILTWMGPV 76
            |:||...:...|||....:||          .:|:.|:             .|:......|:||.
Mouse    36 RQRLLRDLSPFPGPPAHWLLGHQKFLQEDNMETLDEIV-------------KKHPCAFPCWVGPF 87

  Fly    77 -PFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHFNPSFKQDLLL 140
             .|....||...:...|..|  .|.|::...:|.|:|.|||....|.|...|....|:|.||:|.
Mouse    88 QAFFYIYDPDYAKIFLSRTD--PKMQYLHQLLTPCIGRGLLNLDGPRWFQHRCLLTPAFHQDILK 150

  Fly   141 SFFHIFDAETKVLMNLLDTYVDKGE---------IDVVPEMLRWSFKIAAQTTMGSEVKHDEHFK 196
            ..........||::       ||.|         |:|...:...:..|..:...|.|.
Mouse   151 PCVDTMAHSVKVML-------DKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQET------- 201

  Fly   197 NGSLVESFESLISHSTLNILMPLVQNRMISKICGYD---KL--RADNFSRIQKMLDNVVNKKVNP 256
            |..:..::||.:. :|.. |..::.:|:.:....:|   ||  :...|..:.|::.....|.:..
Mouse   202 NCQINGTYESYVK-ATFE-LGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYTEKIIQD 264

  Fly   257 LP-------KTDSDPESNIVINRAMELYRKGDITY--MDVKSECCIMIAAGYDTSALTVYHALFL 312
            ..       |.|....|.|.::..:....:.:..:  .|:::|....:.||:|.||.::...|:.
Mouse   265 RKKILKNQVKQDDTQTSQIFLDIVLSAQAEDERAFSDADLRAEVNTFMWAGHDASAASISWLLYC 329

  Fly   313 LANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRL 377
            ||.:||||:....|:..:..|..  .||:..:.::.|....|||||||||.:|..:||....:.|
Mouse   330 LALNPEHQDRCRTEIRSILGDGS--SITWEQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTL 392

  Fly   378 SNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSK 442
            .:|..:|.|:.:.:.::..|.||.||. |...|:|..|..||.:|:||.|::||:.|.|||||.:
Mouse   393 PDGHSLPAGMTVVLSIWGLHHNPAVWN-DPKVFDPLRFTKENSDQRHPCAFLPFSSGPRNCIGQQ 456

  Fly   443 YAMMSSKFALCRILRNYKIS 462
            :||:..|.|:..||.:::::
Mouse   457 FAMLELKVAIALILLHFQVA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	122/464 (26%)
Cyp4x1	NP_001003947.1	p450	47..499	CDD:278495	122/464 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910