DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	485	Identity:	120/485 - (24%)
Similarity:	217/485 - (44%)	Gaps:	44/485 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKI---PGP------IG-LPILGSSLENIITYKRKLSFRTK 60
            ||||..:....|.|.....::...|::   |.|      :| |.::.||.|.:: |.:.|
Mouse    22 LLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGLIQSSEEGLL-YIQSL----- 80

  Fly    61 YLNKYGSTILTWMGPV-PFIVTRDPKVVEDIFSSPD-CHNKSQHIVNAITSCMGNGLLGKQDPHW 123
             :..:......|:||: |.|....|..::.:..:|. ...|.......:...:|:|||......|
Mouse    81 -VRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWLGDGLLMSTGDKW 144

  Fly   124 LDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSE 188
            ...|:...|:|..::|..:..:|:..|.::.........||...:.      .|:..:..|:.|.
Mouse   145 SRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQRLASKGSAYLN------MFEHISLMTLDSL 203

  Fly   189 VKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRAD--NFSRIQKMLDNVVN 251
            .|....|.:....:..|.:.:...|:.|:.....|::..:..:..|..|  .|.:..:::.:..:
Mouse   204 QKCVFSFDSNCQEKPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTD 268

  Fly   252 KKVNPLPKTDSDPESNIVINRAMELYRKGD---------------ITYMDVKSECCIMIAAGYDT 301
            ..:....:|..| :..:.:.:|....:..|               ::..|:::|....:..|:||
Mouse   269 AVIRERRRTLLD-QGGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDEDIRAEADTFMFGGHDT 332

  Fly   302 SALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPI 366
            :|..:...|:.||.|||:||...:|:..:..|.....|.:.|:.:|.:|...|||:|||.|.:..
Mouse   333 TASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTA 397

  Fly   367 TARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPF 431
            .:|....|:.|.:|.:|||||:..|.:|.||.||.|| ||.:.::|..|.|:|::.:.|.|:|||
Mouse   398 ISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVW-PDPEVYDPFRFDADNVKGRSPLAFIPF 461

  Fly   432 ARGKRNCIGSKYAMMSSKFALCRILRNYKI 461
            :.|.|||||..:||...|.||...|..:::
Mouse   462 SAGPRNCIGQTFAMSEMKVALALTLLRFRV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	113/455 (25%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	113/455 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810