DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	540	Identity:	145/540 - (26%)
Similarity:	249/540 - (46%)	Gaps:	90/540 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VGALFWIYFL--------------------------WSRRRLYFLMLKIPGPIG-LPILGSSLEN 47
            :|.||.:|.|                          |:..|      .|||..| .||:|::|:
Zfish     1 MGILFGLYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMR------PIPGMAGAYPIIGNALQ- 58

  Fly    48 IITYKRKLSFRTK------------YLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKS 100
                     |:|.            ..|::......|:|||||::....:.:|.:.|:      |
Zfish    59 ---------FKTNAGDFFNQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIEVVLSN------S 108

  Fly   101 QHIVNA-----ITSCMGNGLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTY 160
            :|:..:     :...:|.|||......|.:|||...|:|...:|..|..:.:.:|.:|:..:...
Zfish   109 RHLDKSYSYRFLHPWLGTGLLTSTGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKL 173

  Fly   161 VDKGEIDVVPEMLRWSFKIAAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMI 225
            .|....:....:...:..|..:|.||.:: :.:...:...|:|...:....|.....|.:....|
Zfish   174 EDGEPFNCFNFITLCALDIICETAMGKKI-YAQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWI 237

  Fly   226 SKICGYDKLR-----ADNFSRIQKMLDNVVNKK---VNPLPKTDSDP---ESNIVINRAME-LYR 278
                 |:||:     |.....:.....||:.::   ::..|.:|||.   :....::..:: .|.
Zfish   238 -----YNKLKEGKEHAKRLKILHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLLKTTYE 297

  Fly   279 KGD-ITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDA-GHFGITY 341
            .|. :::.|::.|....:..|:||:|.::..||.|:.:|||.|:||..||..||..: .|.|:
Zfish   298 NGQKLSHEDIQEEVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVGV-- 360

  Fly   342 PDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPD 406
            .|::||.|||.||||:||:.|::|:.||.......: ||..:||||...|..:..||:|..: |:
Zfish   361 EDLKKLRYLECVIKESLRIFPSVPLFARSICEACHI-NGFKVPKGVNAVIIPYALHRDPRYF-PE 423

  Fly   407 ADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLV 471
            .:.|.|:.|:.||.:.:||||||||:.|.|||||.::|||..|..|..|||::.:......::|.
Zfish   424 PEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEACQSREELR 488

  Fly   472 YVDNMTMKLAEYPRLKLQRR 491
            .:..:.::..:...:|||||
Zfish   489 PLGELILRPEKGIWIKLQRR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	131/461 (28%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	132/486 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910