DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4f40

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_038935701.1	Gene:	Cyp4f40 / 503122	RGDID:	1559596	Length:	530	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	127/526 - (24%)
Similarity:	223/526 - (42%)	Gaps:	117/526 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGALFW--------IYFLWSR-----------RRLYFLMLKIPGPIGL-PILGSSLENIIT 50
            |||::..:.|        ||.|:::           :|.:|.     |.:|: |.....::.:
  Rat    20 LLLSLVGVSWFLTRCLTQIYTLYAKCQRLCGFPQPPKRSWFW-----GHLGMSPPTEEGMKQM-- 77

  Fly    51 YKRKLSFRTKYLNKYGSTILTWMGP-VPFIVTRDPKVVEDIFS-SPDCHNKSQHIVNAITSCMGN 113
                    |:.:..|....:||:|| ||.|....|.::..:.| |.....|.....:.:...:|:
  Rat    78 --------TELVATYPQGFMTWLGPIVPLITLCHPDIIRSVLSASAAVAPKDGIFYSFLKPWLGD 134

  Fly   114 GLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVL----MNL-------LDTY--VDKGE 165
            |||......|...|....|:|..::|..:..||:..|.::    :.|       ||.:  :....
  Rat   135 GLLVSASDKWSRHRSMLTPAFHFNILKPYVKIFNDSTNIMHAKWLRLASGGSAHLDMFENISLMT 199

  Fly   166 IDVVPEMLRWSFKIAAQTTMGSEVKHDEHFK-----NGSLVESFESLISHSTLNILMPLV-QNRM 224
            :|.:.:.: :||....|.      |..|:..     :..:|:..|.|:.|  :::|..|. ..|.
  Rat   200 LDTLQKCV-FSFNSNCQE------KPSEYIAAILELSALVVKRNEQLLLH--MDLLYRLTPDGRR 255

  Fly   225 ISKIC----------------------GYDKLRADNFSRIQKMLDNVVNKKVNPLPKTDSDPESN 267
            ..|.|                      |.|.::|...|:....:|.::..|       |.|.:
  Rat   256 FYKACHLVHDFTYAVIQERRRTLPKHGGDDVIKAKAKSKTLDFIDVLLLSK-------DEDGK-- 311

  Fly   268 IVINRAMELYRKGDITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFP 332
                         :::..|:::|....:..|:||:|..:...|:.||.|||:||...:|:..:..
  Rat   312 -------------ELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLR 363

  Fly   333 DAGHFGI-------TYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIG 390
            |.....|       ...|:.:|.:|...|||:|||.|.:.:.:|....|:.|.:|.:||||::..
  Rat   364 DRDSEEIECSCGVLLRDDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRVIPKGIICI 428

  Fly   391 IDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRI 455
            |::|.||.||.|| .|.:.::|..|..||::.:.|.|:|||:.|.|||||..:||...|.|:...
  Rat   429 INIFATHHNPTVW-QDPEVYDPFRFDPENIQARSPLAFIPFSAGPRNCIGQTFAMNEMKVAVALT 492

  Fly   456 LRNYKI 461
            |..:::
  Rat   493 LLRFRV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	118/480 (25%)
Cyp4f40	XP_038935701.1	CYP4F	74..522	CDD:410772	115/467 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810