DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	153/523 - (29%)
Similarity:	251/523 - (47%)	Gaps:	50/523 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTINLLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNKYG 66
            :|:.||.:: .:|.:.:...|.||...:.|||||..:|.||:::|..:.:. :|..|...:.|..
  Fly    29 ITVFLLGSI-LIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHD-ELFNRVIGMQKLW 91

  Fly    67 STIL----TWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRR 127
            .|.:    .|.|..|.::..:|:.||.|.:|....||| |..:.:...:|.|||...|..|..||
  Fly    92 GTRIGINRVWQGTAPRVLLFEPETVEPILNSQKFVNKS-HDYDYLHPWLGEGLLTSTDRKWHSRR 155

  Fly   128 KHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEV--- 189
            |...|:|...:|..|..:|:.::.||...|...|.....::.|.:...:..|..:|.||..:
  Fly   156 KILTPAFHFKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQ 220

  Fly   190 --KHDEHFKN----GSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRADNFSRIQKMLDN 248
              ...|:.|.    ||:|:|.::.|          .:|:..|..:....||.....:.:....:.
  Fly   221 SNSESEYVKAVYGIGSIVQSRQAKI----------WLQSDFIFSLTAEYKLHQSYINTLHGFSNM 275

  Fly   249 VVNKKVNPLPKTDSDPESNIVINRAMELY----RKGDITYM----------------DVKSECCI 293
            |:.::...|.....:..:|  .|.|.:.|    :|..:.::                |::.|...
  Fly   276 VIRERKAELAILQENNNNN--NNNAPDAYDDVGKKKRLAFLDLLIDASKEGTVLSNEDIREEVDT 338

  Fly   294 MIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETL 358
            .:..|:||::..:...||||..|||:||.|.|||:.:|.|......|..::..:.|||..||::|
  Fly   339 FMFEGHDTTSAAISWTLFLLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSL 403

  Fly   359 RLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQK 423
            ||.|::|:.||....||.: .|.::|.|....|..:..||||.|: |..:.|||||||.||...:
  Fly   404 RLFPSVPMMARMVGEDVNI-GGKIVPAGTQAIIMTYALHRNPRVF-PKPEQFNPDNFLPENCAGR 466

  Fly   424 HPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDNMTMKLAEYPRLKL 488
            ||:|||||:.|.|||||.|:|::..|..:..:||.|||......:||..:..:.::..:..|:|:
  Fly   467 HPFAYIPFSAGPRNCIGQKFAILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKI 531

  Fly   489 QRR 491
            ..|
  Fly   532 TPR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	139/462 (30%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	142/487 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1194
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	6	5.860