DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	503	Identity:	126/503 - (25%)
Similarity:	217/503 - (43%)	Gaps:	79/503 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGA-------LFWIYFLWSR-----------RRLYFLMLKIPGPIGLPILGSSLENIITYK 52
            |||.|||       |.|.|..:..           :|.:||     |.:||  :.||.|.:: |.
Human    21 LLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFL-----GHLGL--IHSSEEGLL-YT 77

  Fly    53 RKLSFRTKYLNKYGSTILTWMGPVPFIV-TRDPKVVEDIFSSPDC-HNKSQHIVNAITSCMGNGL 115
            :.|:.      .:|.....|:||...|| ...|..::.:..:|.. ..|.:...:.:...:|:||
Human    78 QSLAC------TFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGL 136

  Fly   116 LGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKG--EIDVVPEMLRWSFK 178
            |......|...|:...|:|..::|..:..||:....::.........:|  .:|:        |:
Human   137 LLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDM--------FE 193

  Fly   179 IAAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQ-NRMISK----------ICGYD 232
            ..:..|:.|..|         .|.||:|.........:..::: :.:::|          ...|.
Human   194 HISLMTLDSLQK---------CVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYL 249

  Fly   233 KLRADNFSR----IQKMLDNVVNKKVNPLPKTDSD-------PESNIVINRAMELYRKGD---IT 283
            ......|.|    :....|.|:.::...||....|       ....:.....:.|.:..|   ::
Human   250 TPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLS 314

  Fly   284 YMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLD 348
            ..|:::|....:..|:||:|..:...|:.||.|||:||...:|:..:..|.....|.:.|:.:|.
Human   315 DEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLP 379

  Fly   349 YLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPD 413
            :|...|||:|||.|.:|..:|....|:.|.:|.:||||::..|.:|.||.||.|| ||.:.::|.
Human   380 FLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVW-PDPEVYDPF 443

  Fly   414 NFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461
            .|..:|::::.|.|:|||:.|.|||||..:||...|..|...|..:::
Human   444 RFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	114/458 (25%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	117/472 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810