DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and cyp46a1.2

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_009292815.1	Gene:	cyp46a1.2 / 393433	ZFINID:	ZDB-GENE-040426-1184	Length:	501	Species:	Danio rerio

Alignment Length:	511	Identity:	127/511 - (24%)
Similarity:	216/511 - (42%)	Gaps:	105/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLK---IPGPIGLP----ILGSS--------LENIITYKRKL 55
            ||.||...|..|.|:    ::.|..|   ||||   |    :||.|        .::.:.:...|
Zfish    13 LLSAVFTAFLAYCLY----IHHLHQKYDHIPGP---PRDNFLLGHSPSLTKAMYSDDSLIHDLFL 70

  Fly    56 SFRTKYLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSC-----MGNGL 115
            .:..||...|....|.::.    |:...|:..:.|..||. :.|.....:.:.:.     :||||
Zfish    71 QWAEKYGPVYRINTLHYIA----ILVHCPEATKTILMSPK-YAKDPFSYSRLFNLFGKRFLGNGL 130

  Fly   116 LGKQDPH--WLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRW-SF 177
            :...| |  |..:|:..:|:|....|.|....||..::.||:.|:...:.....|:.:::.. :.
Zfish   131 VTAVD-HDIWYRQRRIMDPAFSSSYLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTL 194

  Fly   178 KIAAQTTMGSEV----KHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDKLRADN 238
            .:..:...|.::    :.|..|:|     :.|..::...|:...||.  |:..|          |
Zfish   195 DVICKVAFGVDLNFLTQKDSPFQN-----AIELCLNGMALDARDPLF--RIFPK----------N 242

  Fly   239 FSRIQKMLDNVV-----------NKKVNPLPKTDSDPESNIV-----------INRAMELYRKGD 281
            :..||::.|..|           |:|.  ..|...|...:|:           :|.:.:|.:..|
Zfish   243 WKLIQQIRDAAVLLRKTGEKWIQNRKT--AVKNGEDVPKDILTQILKIAEEENVNSSEDLEQMMD 305

  Fly   282 --ITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPE---HQEAVFEELNGVFPDAGHFGITY 341
              :|:          ..||.:|:|..:..|:..|..:||   ..:|..:|:.|...:     |:.
Zfish   306 NFVTF----------FIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKRE-----ISN 355

  Fly   342 PDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPD 406
            .|:.||.||.:|:||||||.|..|.|.|....|: :.||:.||.|..:....|.:.| .|.:..|
Zfish   356 EDLGKLTYLSQVLKETLRLYPTAPGTNRWLHEDM-IINGIKIPGGCSVMFSSFVSQR-LEKFFKD 418

  Fly   407 ADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKIS 462
            ...|:|:.| .||..:.: |.|.|||.|.|.|:|..::.|.:|..|.::|:.::.|
Zfish   419 PLKFDPERF-DENAPKPY-YCYYPFALGPRTCLGQVFSQMEAKVVLAKLLQRFEFS 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	117/481 (24%)
cyp46a1.2	XP_009292815.1	p450	39..495	CDD:278495	117/481 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920