DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp49a1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001246256.1	Gene:	Cyp49a1 / 36105	FlyBaseID:	FBgn0033524	Length:	589	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	119/522 - (22%)
Similarity:	213/522 - (40%)	Gaps:	125/522 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KIPGPIGLPILGSS---LENIITYKRKLSFRTKYLNK----YG--STILTWMGPVPFIVTRDPKV 86
            ::|||..||::|:|   ...|.||  |:|...|.:|:    ||  :.:...:|....:...|...
  Fly   102 EVPGPYPLPLIGNSWRFAPLIGTY--KISDLDKVMNELHVNYGKMAKVGGLIGHPDLLFVFDGDE 164

  Fly    87 VEDIFSSPDC--HNKSQHIVNAITSCMGN----------GLLGKQDPHWLDRRKHFNPSFKQDLL 139
            :.:||...:.  |..|   :.::....|:          ||:|...|.|        .:|:|::.
  Fly   165 IRNIFKKEEAMPHRPS---MPSLRHYKGDLRRDFFGDVAGLIGVHGPKW--------EAFRQEVQ 218

  Fly   140 LSFFHIF---DAETKVLMNLLDTYVD--------KGEIDVVP-----EMLRWSFKIAAQTTM--- 185
                ||.   ....|.:..|.|...:        :.|.|.:|     |:.:|:.:...:.::
  Fly   219 ----HILLQPQTAKKYIPPLNDIASEFMGRIELMRDEKDELPANFLHELYKWALESVGRVSLDTR 279

  Fly   186 -------GSEVKHDEHFKNGSLVESFESLI-SHSTLNILMPLVQ----NRMISKICGYDKLRADN 238
                   |||       :...::|:..:.. :...|.:.|||.:    ....|.:...|:..|..
  Fly   280 LGCLSPEGSE-------EAQQIIEAINTFFWAVPELELRMPLWRIYPTKAYRSFVKALDQFTAIC 337

  Fly   239 FSRIQKMLDNVVNKKVNPLPKTDSDPESNIVINRAMELYRK------GDITYMDVKSECCIMIAA 297
            ...|.|.:|.....:...|.|:::|      |:....:.||      ..|..:|       :...
  Fly   338 MKNIGKTMDKADADEARGLSKSEAD------ISIVERIVRKTGNRKLAAILALD-------LFLV 389

  Fly   298 GYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIP 362
            |.||:::.....::.||.:|:.|:.:|:||..|||.. ...|....::::.||...:|||||:.|
  Fly   390 GVDTTSVAASSTIYQLAKNPDKQKKLFDELQKVFPHR-EADINQNVLEQMPYLRACVKETLRMRP 453

  Fly   363 AIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTH--------RNPEVWGPDADNFNPDNFLAEN 419
            .:....|..::|. :.||..:|||         ||        .|...:.|:...|.|:.:|.::
  Fly   454 VVIANGRSLQSDA-VINGYHVPKG---------THVIFPHLVVSNDPAYFPEPKRFLPERWLKQS 508

  Fly   420 ME--------QK-HPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYVDN 475
            .:        || ||:..:||..|:|.|:|.::|.:.....|.:|.|.||:|.::  .:.||..|
  Fly   509 TDAAGCPHANQKIHPFVSLPFGFGRRMCVGRRFAEIELHTLLAKIFRKYKVSYNS--GEFVYRVN 571

  Fly   476 MT 477
            .|
  Fly   572 ST 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	114/504 (23%)
Cyp49a1	NP_001246256.1	p450	104..565	CDD:299894	115/510 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010