DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a1 and Cyp4p2

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_610472.1	Gene:	Cyp4p2 / 35946	FlyBaseID:	FBgn0033395	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	538	Identity:	136/538 - (25%)
Similarity:	243/538 - (45%)	Gaps:	68/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTINLLLAVGALFWIYFLWSRRRLY----FLMLKIPGPIGLP-------------------ILG 42
            |:...|.::|..|..|::::...:.|    |...::....|.|                   :||
  Fly     1 MMICLLWISVAILVVIHWIYKVNKDYNILAFFARRVQTKDGKPLDSLVPMIKGRTVFANCFDLLG 65

  Fly    43 SSLENIITYKRKLSFRTKYLNKYGSTILTW-MGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNA 106
            ...:.:.|:.|:|:      ...|.:.|.: ||...|.|. |.....:|.:.|:...|.. |.|.
  Fly    66 KDTDQVFTHLRQLA------KNSGDSYLQYSMGFSNFNVI-DAHNAANILNHPNLITKGV-IYNF 122

  Fly   107 ITSCMGNGLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGE--IDVV 169
            :...:..|:|...:..|..||.....:|..|:|..|..||.||:   :..:..:..:.|  :.:.
  Fly   123 LHPFLRTGVLTATEKKWHTRRSMLTRTFHLDILNQFQEIFIAES---LKFVSQFQGQNEVVVSLK 184

  Fly   170 PEMLRWSFKIAAQTTMGSEVKHDEHFKNGSLVE-SFESLISHSTLNILMPLVQNRMISKICGYDK 233
            ..:.|::.....:|.||  :|.||..:.|.... :|..:....|..|:.||..:.     |.|:.
  Fly   185 DRISRFTLNSICETAMG--IKLDEMAEKGDRYRANFHIIDEGLTRRIVNPLYWDD-----CVYNM 242

  Fly   234 LRADNFSRIQKML-----DNVVNKKV-------NPLPKTDSDPESNIVINRAMELY-------RK 279
            .....::...|::     :.:..::|       |......:|.:..::..:...:.       :.
  Fly   243 FTGHKYNAALKVVHEFSREIIAKRRVLLEEELENRRATQTADDDICVIRKKRFAMLDTLICAEKD 307

  Fly   280 GDITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEEL-NGVFPDAGHFGITYPD 343
            |.|..:.:..|...::|.||||:::.:...|..::.:...||..::|: ..:..|..:..::  .
  Fly   308 GLIDDIGISEEVDTLMAEGYDTTSIGLVFGLMNMSLYAAEQELCYQEIQEHILDDLSNLNLS--Q 370

  Fly   344 MQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDAD 408
            :.||:||...||||:||.|:|||..|:|..:..|.||:::||...|.|.:|..||||:.| ...:
  Fly   371 LSKLNYLGYFIKETMRLYPSIPIMGRQTLQETELENGLILPKRSQINIHVFDIHRNPKYW-ESPE 434

  Fly   409 NFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKISTSTLYKDLVYV 473
            .|.|:.||.:|..::||||||||:.|:|||||.||||...|..:..||:::||......|.:|:.
  Fly   435 EFRPERFLPQNCLKRHPYAYIPFSAGQRNCIGQKYAMQEMKTLMVVILKHFKILPVIDPKSIVFQ 499

  Fly   474 DNMTMKLAEYPRLKLQRR 491
            ..:|::.....::||.||
  Fly   500 VGITLRFKNKIKVKLVRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	122/472 (26%)
Cyp4p2	NP_610472.1	p450	63..514	CDD:299894	123/471 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	4	3.960