DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp318a1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_727590.1	Gene:	Cyp318a1 / 32172	FlyBaseID:	FBgn0030369	Length:	536	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	122/537 - (22%)
Similarity:	249/537 - (46%)	Gaps:	82/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 INLLL-AVGALFWIYFLWSRRRLYFLMLKIPGPIGL---PIL----------GSSLENIITYKRK 54
            :|:.| |.|||..:...|.:|:.:.|:.::.|..|:   |:|          .|.||.:..|  :
  Fly     3 LNIALWACGALLAVLLAWQQRKCWRLIWQLNGWRGVIQQPVLWLLLCINLHPNSILEKVSQY--R 65

  Fly    55 LSFRTKYLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQ 119
            :.|:.......|:.:|.::.        ||..:|.:.::|:|.:|: .:.:..  .:..|||..:
  Fly    66 VHFQRPLAVLVGTRVLLYID--------DPAGMECVLNAPECLDKT-FLQDGF--FVRRGLLHAR 119

  Fly   120 DPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVD-KGE---IDVVPEML-RWSFKI 179
            ...|..|||..||:|..:::.|||.:|::....::....|..: .|:   .....::| |...::
  Fly   120 GQKWKLRRKQLNPAFSHNIVASFFDVFNSVGNQMVEQFQTQTNLHGQAVKFTAAEDLLSRAVLEV 184

  Fly   180 AAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICG---YDKLRADNFSR 241
            :..|.||:.....: ..:..:..|::.|:..|.:.::.|.:|.|::.::..   |::.:     :
  Fly   185 SCLTIMGTPTNFTQ-LDDAHIAHSYKRLLEISAVRVVKPWLQIRLLHRLLAPELYEESK-----K 243

  Fly   242 IQKMLDNVVNKKVNPL------------PKTDSDP----ESNIVINRAMELYRKGDITYMDVKSE 290
            ..|:|::.|...|...            .|:..|.    :..|.|.:..:|...|::|..::..|
  Fly   244 CAKLLEDFVGGIVRTKHRNWRLRDAVGGEKSGEDASNGWQRRIFIEQIFQLAANGEMTLEEIMDE 308

  Fly   291 CCIMIAAGYDTSALTVYHALFLLA-NHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVI 354
            ...|:...::|.:.::..||..|| |..:.|..:..|:..:.||.|..|:  ..:|:|.||:..:
  Fly   309 AQSMVLVSFETVSNSIMLALLCLATNKGDCQRRLLAEIRALVPDVGQVGL--EQLQQLRYLDAFV 371

  Fly   355 KETLRLIPAIPITARETKNDVRLS---NGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFL 416
            .|:|||:..:|:..|....|.||:   :..::|:..::.:|.|:..|:...||.:|..|:|..||
  Fly   372 SESLRLLATVPMNLRHVSRDFRLAGRQHETIVPQNSIVVLDTFNMQRDERWWGANARQFDPQRFL 436

  Fly   417 AENMEQ-------------------KHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKIS 462
            .:..||                   :|.|:::||:.|.|:|||.:|.:...|..|.:::.|:...
  Fly   437 DQEEEQLSKGHNDSGSGEKRRQRDRRHSYSFLPFSNGLRSCIGRRYGLFIMKVFLVKLITNFDFQ 501

  Fly   463 TSTLYKDLVYVDNMTMK 479
            :....:.|.:|:|:::|
  Fly   502 SDFELEKLQFVENISLK 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	109/489 (22%)
Cyp318a1	NP_727590.1	p450	42..503	CDD:299894	107/481 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450081
Domainoid	1	1.000	82	1.000	Domainoid score	I1949
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	82	1.000	Inparanoid score	I1605
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008559
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24305
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.890