DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	514	Identity:	140/514 - (27%)
Similarity:	220/514 - (42%)	Gaps:	101/514 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGA-------LFWIYFLW--SRRRLYFLMLKIPGP------IG-LPILGSSLENIITYKRK 54
            |||.|||       |..:|.::  |||     :.:.|.|      .| |.::.||.|.:: |.:.
  Rat    21 LLLLVGASCLLAYILPQVYAVFENSRR-----LRRFPQPPTRNWLFGHLGLIQSSEEGLL-YIQS 79

  Fly    55 LSFRTKYLNKYGSTILTWMGP-VPFIVTRDPKVVEDIFSSP-DCHNKSQHIVNAITSCMGNGLLG 117
            || ||     :......|:|| .|.|....|..::.:..:| ....|.:.....:...:|:|||.
  Rat    80 LS-RT-----FRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLL 138

  Fly   118 KQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQ 182
            .....|...|....|:|..::|..:..||:..|.::                  ..:|. ::|:|
  Rat   139 STGDKWSRHRHMLTPAFHFNILKPYVKIFNDSTNIM------------------HAKWQ-RLASQ 184

  Fly   183 TTMGSEVKHDEHFKNGSL------VESFESLISH------STLNILMPLVQNRMISKICGYD--- 232
            .:  :.:...||....:|      |.||:|....      :.:..|..||..|..|.:...|
  Rat   185 GS--ARLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQSLLLYVDLFY 247

  Fly   233 KLRADNFSRIQK-------MLDNVVNKKVNPLPKTDSDPESNIVINRAMELYRKG------DITY 284
            .|..|.. |.:|       ..|.|:.::...||....|.        |::...|.      |:..
  Rat   248 HLTRDGM-RFRKACRLVHDFTDAVIRERRRTLPDQGGDD--------ALKAKAKAKTLDFIDVLL 303

  Fly   285 M------------DVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHF 337
            :            |:::|....:..|:||:|..:...|:.||.|||:||...:|:..:..|....
  Rat   304 LSKDEHGEALSDEDIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPE 368

  Fly   338 GITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEV 402
            .|.:.|:.:|.:|...|||:|||.|.....:|....|:.|.:|.:|||||:..|.:|.||.||.|
  Rat   369 EIEWDDLAQLPFLTMCIKESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAV 433

  Fly   403 WGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461
            | ||.:.:||..|.|:|.|.:.|.|:|||:.|.|||||..:||...|.||...|..:::
  Rat   434 W-PDPEVYNPFRFDADNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRV 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	129/478 (27%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	122/456 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810