Protein Alignment Cyp313a1 and CYP4V2

DIOPT Version :10

• Sequence 1: NP_650368.1
• Gene: Cyp313a1 / 41759
• FlyBaseID: FBgn0038236
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_997235.3
• Gene: CYP4V2 / 285440
• HGNCID: 23198
• Length: 525
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 139/551 - (25%)
• Similarity: 244/551 - (44%)
• Gaps: 109/551 - (19%)

  Fly    15 WIYFLWSRRRLY----FLMLKIPGPIGLPILGSSLENIITYKRK--------------------- 54
            |:..:|.:..|:    .|.|     .|..::.|.|:.:.:|.||
Human     5 WLGLVWQKLLLWGAASALSL-----AGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHAL 64

  Fly    55 -------------LSFRTKYLNKYGSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNA 106
                         :.:..:|  ::...:..|:||||.:...:.:.||.|.:|....:||. :...
Human    65 LMKPDGREFFQQIIEYTEEY--RHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSS-MYKF 126

  Fly   107 ITSCMGNGLLGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPE 171
            :...:|.|||......|..|||...|:|...:|..|..|.:.:..:|:..|:.::::...:....
Human   127 LEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFY 191

  Fly   172 MLRWSFKIAAQTTMGSEV---KHDEH------------------------------FKNGSLVES 203
            :...:..|..:|.||..:   .:|:.                              ||.|  .|.
Human   192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG--WEH 254

  Fly   204 FESL-ISHSTLNILMPLVQNRM-ISKIC-GYDKLRADNFSRIQKMLDNVVNKKVNPLPKTDSDPE 265
            .:|| |.|:..|.::....|.| .::.| |..:..|.:.::.:..||.:::.         :|.|
Human   255 KKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSV---------TDDE 310

  Fly   266 SNIVINRAMELYRKGDITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGV 330
            .|             .:::.|::.|....:..|:||:|..:..:|:||.::||.|:.|..||:.|
Human   311 GN-------------RLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV 362

  Fly   331 FPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFH 395
            |..:.. ..|..|::||.|||.||||||||.|::|:.||....|..:: |..:.||....|..:.
Human   363 FGKSDR-PATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVA-GYRVLKGTEAVIIPYA 425

  Fly   396 THRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYK 460
            .||:|..: |:.:.|.|:.|..||.:.:|||||:||:.|.|||||.|:|:|..|..|..|||::.
Human   426 LHRDPRYF-PNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFW 489

  Fly   461 ISTSTLYKDLVYVDNMTMKLAEYPRLKLQRR 491
            |.::...::|.....:.::.:....:||:||
Human   490 IESNQKREELGLEGQLILRPSNGIWIKLKRR 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	CYP313-like	66..487	CDD:410680	123/456 (27%)
CYP4V2	NP_997235.3	CYP4V	76..515	CDD:410773	124/468 (26%)