DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a1 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	482	Identity:	116/482 - (24%)
Similarity:	205/482 - (42%)	Gaps:	46/482 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTINLLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNKY 65
            :|.:.|||...|..:::..|..:.|.    :.|.|....:.|...|  ..:.::|....:.:..:
Human    24 LLILLLLLIKAAQLYLHRQWLLKALQ----QFPCPPSHWLFGHIQE--FQHDQELQRIQERVKTF 82

  Fly    66 GSTILTWM-GPVPFIVTRDPKVVEDIF--SSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRR 127
            .|....|: |....:...||..::.|.  |.|..|...:.:...|    |.|||......|...|
Human    83 PSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPRI----GYGLLLLNGQTWFQHR 143

  Fly   128 KHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTTMGSEVKHD 192
            :...|:|..|:|..:..:.....:|   :||.:.:....|...|:.:....:...|.|.|...|.
Human   144 RMLTPAFHNDILKPYVGLMADSVRV---MLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQ 205

  Fly   193 EHFKNGSLVESFESLISHSTLN-ILMPLVQNRMISKICGYDKLRADNFSRIQKMLDNVVNKKVNP 256
            ...:.....:|:...|  |.|| ::...::|........|....|..::.....|.:....:|..
Human   206 GSIQVDRNSQSYIQAI--SDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQ 268

  Fly   257 LPKTDSDPESNIVINRAMELYRKGDITYMDV-----------------KSECCIMIAAGYDTSAL 304
            |.|.....|..:     .::.||..:.::|:                 ::|....:..|:||:|.
Human   269 LRKAQLQKEGEL-----EKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTAS 328

  Fly   305 TVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIPITAR 369
            .:...|:.||.||:|||...||::|:..|..  .||:..:.::.|....|||.|||.|.:|...|
Human   329 GISWILYALATHPKHQERCREEIHGLLGDGA--SITWNHLDQMPYTTMCIKEALRLYPPVPGIGR 391

  Fly   370 ETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARG 434
            |....|...:|..:|||:::.:.::..|.||:|| |:.:.|:|..|...:.:  |.:|::||:.|
Human   392 ELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVW-PNLEVFDPSRFAPGSAQ--HSHAFLPFSGG 453

  Fly   435 KRNCIGSKYAMMSSKFALCRILRNYKI 461
            .|||||.::||...|.|....|..:::
Human   454 SRNCIGKQFAMNQLKVARALTLLRFEL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	109/450 (24%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	109/450 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820