DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	134/503 - (26%)
Similarity:	206/503 - (40%)	Gaps:	81/503 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NLLLAVGA-------LFWIYFLWS---RRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRT 59
            :|||..||       |.|||..:.   |.|.:      |.|.........|..:...:..:.|..
  Rat    21 HLLLLGGASWILARILAWIYTFYDNCCRLRCF------PQPPKPSWFWGHLTLMKNNEEGMQFIA 79

  Fly    60 KYLNKYGSTILTWMGPV-PFIVTRDPKVVEDIF-SSPDCHNKSQHIVNAITSCMGNGLLGKQDPH 122
            .....:....|:|:||| |.:....|.|:..:. :|.....|...:...:...:|:|||......
  Rat    80 HLGRNFRDIHLSWVGPVYPILRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGEK 144

  Fly   123 WLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKG--EIDVVPEMLRWSFKIAAQTTM 185
            |...|:...|:|..|:|.|:..||:.....:.........||  .:|:        |:..:..|:
  Rat   145 WNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSARLDM--------FEHISLMTL 201

  Fly   186 GSEVKHDEHFKNGSLVESFESLISHSTLNI------LMPLVQNRMISKICGYD---KLRADNFSR 241
            .|..|         .:.||:|....|....      |..|:..|........|   .|.||. .|
  Rat   202 DSLQK---------CIFSFDSNCQESNSEYIAAILELSSLIVKRQRQPFLYLDFLYYLTADG-RR 256

  Fly   242 IQKMLDNVVN-------------------------KKVNPLPKTDSDPESNIVINRAMELYRKGD 281
            .:|..|.|.|                         .|...|...|       |:..|.:.:.||
  Rat   257 FRKACDVVHNFTDAVIRERRSTLNTQGVDEFLKARAKTKTLDFID-------VLLLAKDEHGKG- 313

  Fly   282 ITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQK 346
            ::.:|:::|....:..|:||:|..:...|:.||.|||:||...:|:..:..|.....|.:.|:.:
  Rat   314 LSDVDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQ 378

  Fly   347 LDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFN 411
            |.:|...|||:|||.|.:.:.:|....|:.|.:|.:||||.:..|.:|..|.||.|| ||.:.:|
  Rat   379 LPFLTMCIKESLRLHPPVLLISRCCSQDIVLPDGRVIPKGNICVISIFGVHHNPSVW-PDPEVYN 442

  Fly   412 PDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNY 459
            |..|..||.:::.|.|:|||:.|.|||||..:||...|.||...|..:
  Rat   443 PFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRF 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	123/465 (26%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	123/465 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810