DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and CYP4Z1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_835235.1	Gene:	CYP4Z1 / 199974	HGNCID:	20583	Length:	505	Species:	Homo sapiens

Alignment Length:	513	Identity:	122/513 - (23%)
Similarity:	212/513 - (41%)	Gaps:	106/513 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTINLLLAVGALFWIYFLWSRRRLYFLMLKI-PGPIG---------LPILGSSLENIITYKRKL 55
            :|.::||     ||.:..|:.|||.....|.: |.|..         .|:            ::.
Human    19 LLCMSLL-----LFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPV------------KEF 66

  Fly    56 SFRTKYLNKYGSTILTWMGP-VPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQ 119
            ....|.:.||...:..|:|| ..|....||...:.:....|..:...|.:  :.|.:|.||:...
Human    67 EVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKI--LESWVGRGLVTLD 129

  Fly   120 DPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGEIDVVPEMLRWSFKIAAQTT 184
            ...|...|:...|.|...:|..|..:.....::::|                  :|...||..:.
Human   130 GSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLN------------------KWEEHIAQNSR 176

  Fly   185 MGSEVKHDEHFKNGSLVESFESLI----SH-------STLNILMPLVQNRMISKICGYDKLRADN 238
            :       |.|::.||: :.:|::    ||       |||:..:..|.|  :|||   ...|.:|
Human   177 L-------ELFQHVSLM-TLDSIMKCAFSHQGSIQLDSTLDSYLKAVFN--LSKI---SNQRMNN 228

  Fly   239 F---------------------SRIQKMLDNVVNKKVNPLP---KTDSDPES-----NIVINRAM 274
            |                     ..:.:..:.|:..:...|.   |.|:..:.     :|:::...
Human   229 FLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKS 293

  Fly   275 ELYRKGDITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGI 339
            |  ...|.:..|:::|....:.||:||::..:...|:.||.:||||:...:|:..:..|..  .|
Human   294 E--NTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGS--SI 354

  Fly   340 TYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWG 404
            |:..:.::.|....|||.|||...:...:|.....:...:|..:|.|:.:.|:::..|.||..|
Human   355 TWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFW- 418

  Fly   405 PDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKIS 462
            .|...|||..|..||.|:.||||:|||:.|.|||||..:|::..|.|:...|..:|::
Human   419 EDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	112/480 (23%)
CYP4Z1	NP_835235.1	p450	47..500	CDD:278495	112/480 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D825914at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920