DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp313a1 and Cyp4f13

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_570952.1	Gene:	Cyp4f13 / 170716	MGIID:	2158641	Length:	523	Species:	Mus musculus

Alignment Length:	513	Identity:	133/513 - (25%)
Similarity:	211/513 - (41%)	Gaps:	98/513 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NLLLAVGA-------LFWIYFLW---SRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRT 59
            :|||..||       |.|||..:   ||.|.:      |.|.........|..:...:..:.|.|
Mouse    20 HLLLLGGASWILARILAWIYAFYDNCSRLRCF------PQPPKPSWFWGHLALMKNNEESMQFIT 78

  Fly    60 KYLNKYGSTILTWMGPV-PFIVTRDPKVVEDIF-SSPDCHNKSQHIVNAITSCMGNGLLGKQDPH 122
            ...:.:....|:|:||| |.:....|..:..:. :|.....|...:...:...:|:|||......
Mouse    79 HLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKPWLGDGLLMSAGDK 143

  Fly   123 WLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKG--EIDV--------VPEMLRWSF 177
            |...|:...|:|..|:|.|:..||:....::.........||  .:|:        :..:.:..|
Mouse   144 WSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLDMFEHISLMTLDSLQKCIF 208

  Fly   178 K------------IAAQTTMGSEV--KHDEHF-----------------KNGSLVESFESLI--- 208
            .            |||...:.|.|  :|.:.|                 |...||.:|...:
Mouse   209 SVDSNCQESDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKE 273

  Fly   209 SHSTLNILMPLVQNRMISKICGYDKLRADNFSRIQKMLDNVVNKKVNPLPKTDSDPESNIVINRA 273
            ..||||..             |.:.|:|...::....:|                     |:..|
Mouse   274 RRSTLNTQ-------------GVEFLKAKAKTKTLDFID---------------------VLLMA 304

  Fly   274 MELYRKGDITYMDVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFG 338
            .:.:.|| ::..|:::|....:..|:||:...:...|:.||.|||:||...:|:..:..|.....
Mouse   305 EDEHGKG-LSNEDIRAEADTFMFGGHDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEE 368

  Fly   339 ITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVW 403
            |.:.|:.:|.:|...|||:|||.|.:.:.:|....||.|.:|..||||.:..|.:|..|.||.||
Mouse   369 IEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAIPKGNICVISIFGVHHNPSVW 433

  Fly   404 GPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461
             ||.:.:||..|..||.:::.|.|:|||:.|.|||||..:||...|.||...|..::|
Mouse   434 -PDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFAMSEIKVALALTLLRFRI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	121/475 (25%)
Cyp4f13	NP_570952.1	p450	52..513	CDD:278495	121/475 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810