DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and CYP19A1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_000094.2	Gene:	CYP19A1 / 1588	HGNCID:	2594	Length:	503	Species:	Homo sapiens

Alignment Length:	507	Identity:	123/507 - (24%)
Similarity:	209/507 - (41%)	Gaps:	115/507 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TINLLLAVGALFWIYFLWSRRRLYFLMLKIPGP-----IGLPILGSSLENIITYKRKL----SFR 58
            |:.:||..| ||.:  :|:    |.....||||     ||         .:|::.|.|    ...
Human    25 TMPVLLLTG-LFLL--VWN----YEGTSSIPGPGYCMGIG---------PLISHGRFLWMGIGSA 73

  Fly    59 TKYLNK-YGSTILTWM-GPVPFIVTRDPKVVEDIFSSPDCH-NKSQHIVNAITS-----CMG--- 112
            ..|.|: ||..:..|: |....|:::         ||...| .|..|..:...|     |:|
Human    74 CNYYNRVYGEFMRVWISGEETLIISK---------SSSMFHIMKHNHYSSRFGSKLGLQCIGMHE 129

  Fly   113 NGLLGKQDPH-WLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYV-DKGEIDVVPEMLRW 175
            .|::...:|. |...|..|..:.....|:....:.....|..::.|:... :.|.:||: .:||
Human   130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVL-TLLR- 192

  Fly   176 SFKIAAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMISKICGYDK------L 234
              ::...|:                          :||.:.:||.::.::.||.||..      :
Human   193 --RVMLDTS--------------------------NTLFLRIPLDESAIVVKIQGYFDAWQALLI 229

  Fly   235 RADNFSRIQKMLDNVVNKKVNPLP------------KTDSDPESNIVINRAMELY---RKGDITY 284
            :.|.|.:| ..|.....|.|..|.            :..::.:....::.|.||.   ::||:|.
Human   230 KPDIFFKI-SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTR 293

  Fly   285 MDVKSECCI-MIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLD 348
            .:| ::|.: |:.|..||.:::::..|||:|.||..:||:.:|:..|.   |...|...|:|||.
Human   294 ENV-NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI---GERDIKIDDIQKLK 354

  Fly   349 YLERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNF-NP 412
            .:|..|.|::|..|.:.:..|:...| .:.:|..:.||..|.:::...||        .:.| .|
Human   355 VMENFIYESMRYQPVVDLVMRKALED-DVIDGYPVKKGTNIILNIGRMHR--------LEFFPKP 410

  Fly   413 DNFLAENMEQKHPYAYI-PFARGKRNCIGSKYAMMSSKFALCRILRNYKIST 463
            :.|..||..:..||.|. ||..|.|.|.|...||:..|..|..:||.:.:.|
Human   411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKT 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	113/475 (24%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	106/444 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910