DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and CYP4B1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001093242.1	Gene:	CYP4B1 / 1580	HGNCID:	2644	Length:	512	Species:	Homo sapiens

Alignment Length:	493	Identity:	126/493 - (25%)
Similarity:	216/493 - (43%)	Gaps:	60/493 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNKYGSTIL 70
            |:|.:|.|..|:.|..|:.|...|.|.|||....:.|.:||  |.....|.....:.:::.....
Human    20 LILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALE--IQETGSLDKVVSWAHQFPYAHP 82

  Fly    71 TWMGP-VPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRKHFNPSF 134
            .|.|. :.|:...:|...:.::|..|  .|:..:.:.....:|.|||..:.|.||..||...|.|
Human    83 LWFGQFIGFLNIYEPDYAKAVYSRGD--PKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGF 145

  Fly   135 KQDLLLSFFHIFDAETKVLMNLLDTYVDKGE-IDVVPEMLRWSFKIAAQTTMGSEVKHDEHFKNG 198
            ..|:|..:..:|...|:::::..:....:|: .|:..::...:.....:.|.|.......|.::
Human   146 HYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRD- 209

  Fly   199 SLVESFESLISHSTLNILMPLVQNRMIS-------------------KICGYDKLRADNFSRIQK 244
               .|:...:|..||     |:|.|::|                   :.|.......|...|.:|
Human   210 ---SSYYLAVSDLTL-----LMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERK 266

  Fly   245 --MLDNVVNKKVNPLPKTD-------SDPESNIVINRAMELYRKGDITYMDVKSECCIMIAAGYD 300
              :.|..|.||:......|       :..|.:|.::.|            |:::|....:..|:|
Human   267 AALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDA------------DLRAEVDTFMFEGHD 319

  Fly   301 TSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIKETLRLIPAIP 365
            |:...:...|:.:|.:||||....||:..:..|...|  .:.|:.|:.||...|||:.||.|.:|
Human   320 TTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFF--QWDDLGKMTYLTMCIKESFRLYPPVP 382

  Fly   366 ITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIP 430
            ...|:....|...:|..:|.|.:|.:.::..|||..|| ||.:.|:...|..||..::||:|::|
Human   383 QVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW-PDPEVFDSLRFSTENASKRHPFAFMP 446

  Fly   431 FARGKRNCIGSKYAMMSSKF--ALCRILRNYKISTSTL 466
            |:.|.|||||.::||...|.  |:|.:...:.:..|.|
Human   447 FSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRL 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	114/461 (25%)
CYP4B1	NP_001093242.1	p450	47..501	CDD:306555	116/466 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810