DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp26a1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_569092.2	Gene:	Cyp26a1 / 154985	RGDID:	620161	Length:	497	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	118/472 - (25%)
Similarity:	208/472 - (44%)	Gaps:	40/472 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTINLLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNKY 65
            :|.:.|.||...|:.:|.:.||.|...|.|. ||.:|.|..|.:|:.::..::.|..:.:   ||
  Rat    15 VLPLLLFLAALKLWDLYCVSSRDRSCALPLP-PGTMGFPFFGETLQMVLQRRKFLQMKRR---KY 75

  Fly    66 GSTILTWMGPVPFIVTRDPKVVEDIFSSPDCHN-KSQHIVNAITSCMGNGLLGK-QDPHWLDRRK 128
            |....|.:...|.:.......|..|....  |. .|.|...::.:.:|.|.|.. .|.....|:|
  Rat    76 GFIYKTHLFGRPTVRVMGADNVRRILLGE--HRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKK 138

  Fly   129 HFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGE--IDVVPEMLRWSFKIAAQTTMGSEV-- 189
            ....:|.::.|..:..:...|   :...|:.::..||  :.|.||:.|..|:||.:..:|.|.
  Rat   139 VIMQAFNREALQCYVPVIAEE---VSGCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGP 200

  Fly   190 ---KHDEHFKNGSLVESFESLISHSTLNIL-MPLVQNRMISKICGYDKLRADNFSRIQKMLDNVV 250
               ..||.    .|||:||.:    |.|:. :|:  :...|.:  |..::|.|.  |...::..:
  Rat   201 AGGGEDEQ----QLVEAFEEM----TRNLFSLPI--DVPFSGL--YRGVKARNL--IHARIEENI 251

  Fly   251 NKKVNPLPKTDSDPESNIVINRAME-LYRKGD-ITYMDVKSECCIMIAAGYDTSALTVYHALFLL 313
            ..|:..|...:.|......:...:| .:.:|: :....:|.....::..|::|:|......:..|
  Rat   252 RAKIRRLQAAEPDAGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYL 316

  Fly   314 ANHPEHQEAVFEEL--NGVFPDAGHFG-ITYPDMQKLDYLERVIKETLRLIPAIPITARETKNDV 375
            ..:|...:.|.||:  .|:...:.|.. :....:::|.|:..||||||||.|.:|...|......
  Rat   317 GLYPHVLQKVREEIKSKGLLCKSHHEDKLDMETLEQLKYIGCVIKETLRLNPPVPGGFRVALKTF 381

  Fly   376 RLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENMEQKHPYAYIPFARGKRNCIG 440
            .| ||..||||..:...:..||...:.: .:.:.||||.|.:.:.|....:::|||..|.|:|:|
  Rat   382 EL-NGYQIPKGWNVIYSICDTHDVADSF-TNKEEFNPDRFTSLHPEDTSRFSFIPFGGGLRSCVG 444

  Fly   441 SKYAMMSSKFALCRILR 457
            .::|.:..|.....:.|
  Rat   445 KEFAKILLKIFTVELAR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	107/440 (24%)
Cyp26a1	NP_569092.2	p450	43..491	CDD:299894	108/444 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000