DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_031849.1	Gene:	Cyp4b1 / 13120	MGIID:	103225	Length:	511	Species:	Mus musculus

Alignment Length:	498	Identity:	125/498 - (25%)
Similarity:	213/498 - (42%)	Gaps:	90/498 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGALFWIYFLWSRRRLYFLMLKIPGPIGLPILGSSLE--------NIITYKRKLSFRTKYL 62
            ::|.|..|..:..|:.|::|...:...|||....:.|.:||        .::|:..:..:...
Mouse    20 VILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFPYAHP-- 82

  Fly    63 NKYGSTILTWMGP-VPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDR 126
                    .|:|. :.|:...:|...:.::|..|  .|:.::.:.....:|.|||..:.|.|...
Mouse    83 --------LWLGQFIVFLNIYEPDYAKAVYSRGD--PKAAYVYDFFLQWIGKGLLVLEGPKWFQH 137

  Fly   127 RKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKG----EIDVVPEMLRWSFKIAAQTTMG- 186
            ||...|.|..|:|..:..||...|:|   :||.:..|.    ..|:..::...:.....:.|.|
Mouse   138 RKLLTPGFHYDVLKPYVAIFAESTRV---MLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGK 199

  Fly   187 --SEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMIS-------------------KICG 230
              |.:.|.::        |:...:|..||     |:|.|:.|                   :.|.
Mouse   200 GDSGLSHSDN--------SYYLAVSDLTL-----LMQQRIDSFQYHNDFIYWLTPHGRRFLRACQ 251

  Fly   231 YDKLRADNFSRIQK--MLDNVVNKKVNPLPKTD-------SDPESNIVINRAMELYRKGDITYMD 286
            ......|:..|.:|  :.|....||:......|       :..||.|.::.|            |
Mouse   252 IAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGARDESGIKLSDA------------D 304

  Fly   287 VKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLE 351
            :::|....:..|:||:...:...|:.:|.:|.||:...||:..:..|...|  .:.|:.::.||.
Mouse   305 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSF--QWDDLAQMTYLT 367

  Fly   352 RVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFL 416
            ..:||..||.|.:|...|:....|...:|..:|.|.:|.:.::..|||..|| ||.:.|:|..|.
Mouse   368 MCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVW-PDPEVFDPLRFS 431

  Fly   417 AENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKF--ALCRILR 457
            .|||..:||:|::||:.|.|||||.::||...|.  ||| :||
Mouse   432 PENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALC-LLR 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	119/471 (25%)
Cyp4b1	NP_031849.1	p450	47..500	CDD:278495	119/471 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810