DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and Cyp4a14

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_031848.1	Gene:	Cyp4a14 / 13119	MGIID:	1096550	Length:	507	Species:	Mus musculus

Alignment Length:	501	Identity:	120/501 - (23%)
Similarity:	207/501 - (41%)	Gaps:	87/501 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLTINLLLAVGALFWIYFLWSRRRL-YFLMLKIPGPIGLPILGSSLENIITYKRKLSFRTKYLNK 64
            :|::.|:|.....|::...|..:.| :|..:......|..:....|:.|:.          ::.|
Mouse    24 LLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGHHLKDKELQQILI----------WVEK 78

  Fly    65 YGSTILTWM-GPVPFIVTRDPKVVEDIFSSPDCHNKSQHIVNAITSCMGNGLLGKQDPHWLDRRK 128
            :.|..|..: |....::..||..|:.:....|  .|:..|.......:|.|||......|...|:
Mouse    79 FPSACLQCLSGSNIRVLLYDPDYVKVVLGRSD--PKASGIYQFFAPWIGYGLLLLNGKKWFQHRR 141

  Fly   129 HFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGE-------------------IDVVPEMLR 174
            ...|:|..|:|..:       .|::.:.::..:||.|                   :|.|.:
Mouse   142 MLTPAFHYDILKPY-------VKIMADSVNIMLDKWEKLDGQDHPLEIFHCVSLMTLDTVMK--- 196

  Fly   175 WSFKIAAQTTMGSEVKHDEHFK-NGSLVESFESLI------SHSTLNILMPLVQN-RMISKIC-- 229
                 .|.:..|| |:.||:.| ....||...:|.      :....||:..:..: |:....|
Mouse   197 -----CAFSYQGS-VQLDENSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQI 255

  Fly   230 ------GYDKLR---ADNFSRIQKMLDNVVNKKVNPLPKTDSDPESNIVINRAMELYRKGDITYM 285
                  |..|:|   ..|...:||.      :|...|...|      |::...||  .:..::..
Mouse   256 AHEHTDGVIKMRKSQLQNEEELQKA------RKKRHLDFLD------ILLFARME--DRNSLSDE 306

  Fly   286 DVKSECCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYL 350
            |:::|....:..|:||:|..:....:.||.|||||:...||:..:..|.  ..:|:..:.::.|.
Mouse   307 DLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDG--TSVTWDHLGQMPYT 369

  Fly   351 ERVIKETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNF 415
            ...|||.|||.|.:...:||..:.|...:|..||||:...|.::..|.||..| |:...|:|..|
Mouse   370 TMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPKGITATISIYGLHHNPRFW-PNPKVFDPSRF 433

  Fly   416 LAENMEQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461
            ..::  ..|.:||:||:.|.|||||.::||...|.|:...|..:::
Mouse   434 APDS--SHHSHAYLPFSGGSRNCIGKQFAMNELKVAVALTLLRFEL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	113/468 (24%)
Cyp4a14	NP_031848.1	p450	52..501	CDD:278495	113/473 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810