DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp313a1 and CYP4F8

DIOPT Version :9

Sequence 1:	NP_650368.1	Gene:	Cyp313a1 / 41759	FlyBaseID:	FBgn0038236	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_009184.1	Gene:	CYP4F8 / 11283	HGNCID:	2648	Length:	520	Species:	Homo sapiens

Alignment Length:	496	Identity:	133/496 - (26%)
Similarity:	211/496 - (42%)	Gaps:	65/496 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLAVGA-------LFWIY-FLWSRRRL----------YFLMLKIPGPIGLPILGSSLENIITYK 52
            |||.|||       |.|.| |..:.|||          :||     |.:||         :...:
Human    21 LLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFL-----GHLGL---------VTPTE 71

  Fly    53 RKLSFRTKYLNKYGSTILTWMGPV-PFIVTRDPKVVEDIFSSPDC-HNKSQHIVNAITSCMGNGL 115
            ..|...|:.:..|....:.|:||: |.|....|.:|..:.::.|. .:|.......:...:|:||
Human    72 EGLRVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGL 136

  Fly   116 LGKQDPHWLDRRKHFNPSFKQDLLLSFFHIFDAETKVLMNLLDTYVDKGE--IDVVPEMLRWSFK 178
            |......|...|:...|:|..::|..:..||.....::.........:|.  :||        |:
Human   137 LLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGSTCLDV--------FE 193

  Fly   179 IAAQTTMGSEVKHDEHFKNGSLVESFESLISHSTLNILMPLVQNRMIS--------KICGYDKLR 235
            ..:..|:.|..|....|.:....:..|.:.:...|:.|:....|:...        ..||....|
Human   194 HISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHR 258

  Fly   236 ADNFSRIQKMLDNVVNKKVNPL----------PKTDSDPESNIVINRAMELYRKGDITYMDVKSE 290
            |...  :....|.|:.::...|          .|..|.....|.:....|.....:::..|:::|
Human   259 ACRL--VHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAE 321

  Fly   291 CCIMIAAGYDTSALTVYHALFLLANHPEHQEAVFEELNGVFPDAGHFGITYPDMQKLDYLERVIK 355
            ....:..|:||:|..:...|:.||.|||:||...:|:..:..|.....|.:.|:.:|.:|...:|
Human   322 ADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLK 386

  Fly   356 ETLRLIPAIPITARETKNDVRLSNGVLIPKGVVIGIDMFHTHRNPEVWGPDADNFNPDNFLAENM 420
            |:|||.|.||..||....||.|.:..:||||.|..|::|..|.||.|| ||.:.::|..|..||.
Human   387 ESLRLHPPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVW-PDPEVYDPFRFDPENA 450

  Fly   421 EQKHPYAYIPFARGKRNCIGSKYAMMSSKFALCRILRNYKI 461
            :::.|.|:|||:.|.|||||.|:||...|..|...|..::|
Human   451 QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp313a1	NP_650368.1	p450	33..463	CDD:299894	118/451 (26%)
CYP4F8	NP_009184.1	p450	52..504	CDD:306555	120/465 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810