DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and HTRA3

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_444272.1	Gene:	HTRA3 / 94031	HGNCID:	30406	Length:	453	Species:	Homo sapiens

Alignment Length:	400	Identity:	161/400 - (40%)
Similarity:	238/400 - (59%)	Gaps:	59/400 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 AANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAIIQREDLTPT 90
            ||:||:.||:   |.|                   .|:|.:...|..|
Human   105 AASRRALQLS---GTP-------------------VRQLQKGACPLGL----------------- 130

  Fly    91 IAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTN 155
               .:::..|..||||||||...|.:||:||: ..||  ...|:.:..|:|||||:.:.|||:||
Human   131 ---HQLSSPRYKFNFIADVVEKIAPAVVHIEL-FLRH--PLFGRNVPLSSGSGFIMSEAGLIITN 189

  Fly   156 AHVVINKP----HTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQ-VNNLSVMRLGKSSTLRSGE 215
            ||||.:..    ...::|:|.:|.::.|||:|:|:.||:||::|. ...|.|:.||.|:.||.||
Human   190 AHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGE 254

  Fly   216 WVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGV 280
            :|||:|||.||.||||.|::|:.||..:|||||:.|::|:||||.|.:|||||||||||||.||:
Human   255 FVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGI 319

  Fly   281 NSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQ 345
            |::|||||||||||.|.:..||....:|:.|.  :|     ||::||.|.|:||.::.|||:.:.
Human   320 NTLKVTAGISFAIPSDRITRFLTEFQDKQIKD--WK-----KRFIGIRMRTITPSLVDELKASNP 377

  Fly   346 NMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGV 410
            :.| .::.|:.|.:|...||:..||:|.|||:..:|.:.:.:||::.:|:...|..| :.:.||.
Human   378 DFP-EVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLL-LEVRRGN 440

  Fly   411 KQMHVTITPE 420
            ..:..:|.||
Human   441 DDLLFSIAPE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	150/358 (42%)
		Trypsin_2	141..280	CDD:290102	78/143 (55%)
		PDZ_serine_protease	323..417	CDD:238487	30/93 (32%)
HTRA3	NP_444272.1	IGFBP	25..76	CDD:278641
		Kazal_2	81..126	CDD:284958	10/42 (24%)
		Serine protease	175..340		92/164 (56%)
		Trypsin_2	175..319	CDD:290102	78/143 (55%)
		PDZ_serine_protease	355..440	CDD:238487	29/86 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3884
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2690
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm42040
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	O	PTHR22939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2207
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860