DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and NMA111

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_014276.1	Gene:	NMA111 / 855600	SGDID:	S000005067	Length:	997	Species:	Saccharomyces cerevisiae

Alignment Length:	337	Identity:	90/337 - (26%)
Similarity:	146/337 - (43%)	Gaps:	40/337 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQN-GLILTNAHVVINKPHTMV 167
            |.|::||    .|||.|.......||..|.   ..|..:||:::.. |:||||.|||  .|...|
Yeast    74 NTISNVV----KSVVSIHFSQVAPFDCDSA---LVSEATGFVVDAKLGIILTNRHVV--GPGPFV 129

  Fly   168 QVRLSDGRTFPATIEDV-------DQTSDLATLRIQVNNLSVMRLG----KSSTLRSGEWVVALG 221
            ...:.|..      |:.       |...|...|:....|:...::.    |.|..:.|..:..:|
Yeast   130 GYVVFDNH------EECDVIPIYRDPVHDFGFLKFDPKNIKYSKIKALTLKPSLAKVGSEIRVVG 188

  Fly   222 SPLALSNTVTAGVISSTQRASQELG-LRNRDIN--YLQTDAAITFGNSGGPLVNLDGEAIGVNSM 283
            :......::.||.||...|.:.|.| |...|.|  |:|..|:.:.|:||.|:||:||.|:.:.:.
Yeast   189 NDAGEKLSILAGFISRIDRNAPEYGELTYNDFNTEYIQAAASASGGSSGSPVVNIDGYAVALQAG 253

  Fly   284 KVT-AGISFAIPIDYV-KVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQN 346
            ..| |...|.:|:|.: :..:.....|.......:..:.:|.|.....|.||.:...|.:::
Yeast   254 GSTEASTDFFLPLDRILRALICIQTNKPITRGTIQVQWLLKPYDECRRLGLTSERESEARAK--- 315

  Fly   347 MPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNS--KTLDIVILRG 409
            .|.|:  |:||.:.::........::.||.:..||.:.|.:...| |.:.|.:  |.:.:||.||
Yeast   316 FPENI--GLLVAETVLREGPGYDKIKEGDTLISINGETISSFMQV-DKIQDENVGKEIQLVIQRG 377

  Fly   410 VKQMHVTITPED 421
            ..:..||.|..|
Yeast   378 GVECTVTCTVGD 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	90/337 (27%)
		Trypsin_2	141..280	CDD:290102	44/153 (29%)
		PDZ_serine_protease	323..417	CDD:238487	24/95 (25%)
NMA111	NP_014276.1	DegQ	48..391	CDD:223343	90/337 (27%)
		PDZ_1	392..469	CDD:372324
		DegQ	543..870	CDD:223343
		PDZ	<810..862	CDD:412172
		PDZ	869..944	CDD:412172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2844
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5040
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto100166
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2207
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.750