Protein Alignment HtrA2 and NAS2

DIOPT Version :9

• Sequence 1: NP_001262565.1
• Gene: HtrA2 / 41756
• FlyBaseID: FBgn0038233
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_012259.3
• Gene: NAS2 / 854810
• SGDID: S000001269
• Length: 220
• Species: Saccharomyces cerevisiae
• Alignment Length: 209
• Identity: 39/209 - (18%)
• Similarity: 76/209 - (36%)
• Gaps: 48/209 - (22%)

  Fly   236 SSTQRASQ-------ELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAI 293
            |.|.|.||       ||.:...||. .|.:|..:.         |:.:.||::|..||.......
Yeast    18 SLTSRISQIDSFKLSELMVLKTDIE-TQLEAYFSV---------LEQQGIGMDSALVTPDGYPRS 72

  Fly   294 PIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSN-------- 350
            .:|.::|.:.|......|..             :..|.....:|......:.|:.||
Yeast    73 DVDVLQVTMIRKNVNMLKND-------------LNHLLQRSHVLLNQHFDNMNVKSNQDARRNND 124

  Fly   351 ---LTHGV---LVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYD----ALADNSKTLDIV 405
               :.:.:   .:.:|:.|||:....::..|.:..|......|.|.:.:    .:.:..:.|.::
Yeast   125 DQAIQYTIPFAFISEVVPGSPSDKADIKVDDKLISIGNVHAANHSKLQNIQMVVMKNEDRPLPVL 189

  Fly   406 ILRGVKQMHVTITP 419
            :||..:.:..::||
Yeast   190 LLREGQILKTSLTP 203

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	39/209 (19%)
		Trypsin_2	141..280	CDD:290102	13/50 (26%)
		PDZ_serine_protease	323..417	CDD:238487	16/111 (14%)
NAS2	NP_012259.3	Nas2_N	31..109	CDD:408080	18/100 (18%)
		PDZ	106..182	CDD:395476	11/75 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900