DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and DEG14

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001330700.1	Gene:	DEG14 / 832828	AraportID:	AT5G27660	Length:	435	Species:	Arabidopsis thaliana

Alignment Length:	327	Identity:	131/327 - (40%)
Similarity:	187/327 - (57%)	Gaps:	26/327 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVI---NKPHT-- 165
            ||:..|....:||.:.:...     |.|..:..|.|||.||:.:|.|||.||||:   |..|:
plant   119 IANAAARIGPAVVNLSVPQG-----FHGISMGKSIGSGTIIDADGTILTCAHVVVDFQNIRHSSK 178

  Fly   166 -MVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN-LSVMRLGKSSTLRSGEWVVALGSPLALSN 228
             .|.|.|.|||||...:.:.|..||:|.::|:... |...:||.||.||.|:||:|:|.||:|.|
plant   179 GRVDVTLQDGRTFEGVVVNADLQSDIALVKIKSKTPLPTAKLGFSSKLRPGDWVIAVGCPLSLQN 243

  Fly   229 TVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTA--GISF 291
            |||||::|...|.|.:|||..:...|||||.:|..|||||||||||||.||||.|||.|  |:.|
plant   244 TVTAGIVSCVDRKSSDLGLGGKHREYLQTDCSINAGNSGGPLVNLDGEVIGVNIMKVLAADGLGF 308

  Fly   292 AIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVL 356
            ::|||.|...:|...         |:|..::.::|:.|:.|...|:.:||.|....| ::..|||
plant   309 SVPIDSVSKIIEHFK---------KSGRVIRPWIGLKMVELNNLIVAQLKERDPMFP-DVERGVL 363

  Fly   357 VWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADN-SKTLDIVILRGVKQ-MHVTITP 419
            |..||.||||...|.:|||:|...:.|.::...:|.:.:.|. .|.:.:|:.|..|: :.:.:.|
plant   364 VPTVIPGSPADRAGFKPGDVVVRFDGKPVETIKEVIEIMDDRVGKRMQVVVERSNKERVTLEVIP 428

  Fly   420 ED 421
            |:
plant   429 EE 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	131/327 (40%)
		Trypsin_2	141..280	CDD:290102	75/145 (52%)
		PDZ_serine_protease	323..417	CDD:238487	30/95 (32%)
DEG14	NP_001330700.1	degP_htrA_DO	117..>432	CDD:273938	131/327 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1574
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	196	1.000	Inparanoid score	I1342
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D630723at2759
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		oto3581
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	LDO	PTHR22939
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830