DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and DEG5

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_567552.2	Gene:	DEG5 / 827564	AraportID:	AT4G18370	Length:	323	Species:	Arabidopsis thaliana

Alignment Length:	361	Identity:	99/361 - (27%)
Similarity:	151/361 - (41%)	Gaps:	113/361 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MALRGSHRLEVIFKR----------CIASPVLHSHAAN-RRSSQLAIKEGDPNSNGNSGQYQQNG 54
            :|..||:.::||.:|          .:.|.:|.|:... ...|.:|::           |:::..
plant    28 LACSGSNHVDVIDRRRRIMIFGSSLALTSSLLGSNQQRLPMESAIALE-----------QFKEKE 81

  Fly    55 EQKEKGWRRLVRFFVPFSLGAVVSAAIIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVY 119
            |:.|:...|.|..|                :..:|                          ||||
plant    82 EELEEEEERNVNLF----------------QKTSP--------------------------SVVY 104

  Fly   120 IEIKDTRHFDYFSGQPIT-------ASNGSGFIIEQNGLILTNAHVVINKPHTM-----VQVRLS 172
            ||..:.....  ||..:|       ...||||:.::.|.|:||.||:.......     .:|.|.
plant   105 IEAIELPKTS--SGDILTDEENGKIEGTGSGFVWDKLGHIVTNYHVIAKLATDQFGLQRCKVSLV 167

  Fly   173 D--GRTF--PATIEDVDQTSDLATLRIQV--NNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVT 231
            |  |..|  ...|..:|..:|||.|:|:.  ..|:.:.||.|:.||.|:...|:|:|....||:|
plant   168 DAKGTRFSKEGKIVGLDPDNDLAVLKIETEGRELNPVVLGTSNDLRVGQSCFAIGNPYGYENTLT 232

  Fly   232 AGVISSTQRASQELGLRN-RDIN-YLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVT-------A 287
            .||:|...|   |:...| :.|: .:||||.|..|||||||::..|..||||:...|       :
plant   233 IGVVSGLGR---EIPSPNGKSISEAIQTDADINSGNSGGPLLDSYGHTIGVNTATFTRKGSGMSS 294

  Fly   288 GISFAIPID-------YVKVFLERAAEKRKKGSAYK 316
            |::||||||       |:.|:          |:||:
plant   295 GVNFAIPIDTVVRTVPYLIVY----------GTAYR 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	83/284 (29%)
		Trypsin_2	141..280	CDD:290102	56/151 (37%)
		PDZ_serine_protease	323..417	CDD:238487
DEG5	NP_567552.2	Trypsin_2	131..280	CDD:290102	56/151 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D630723at2759
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.780