Protein Alignment HtrA2 and Htra3

DIOPT Version :10

• Sequence 1: NP_650366.1
• Gene: HtrA2 / 41756
• FlyBaseID: FBgn0038233
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: XP_006504249.1
• Gene: Htra3 / 78558
• MGIID: 1925808
• Length: 467
• Species: Mus musculus
• Alignment Length: 332
• Identity: 150/332 - (45%)
• Similarity: 219/332 - (65%)
• Gaps: 11/332 - (3%)

  Fly    95 KMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVV 159
            ::|..|..||||||||...|.:||:||: ..||  ...|:.:..|:|||||:.:.|||:||||||
Mouse   138 QLTSPRYKFNFIADVVEKIAPAVVHIEL-FLRH--PLFGRNVPLSSGSGFIMSEAGLIVTNAHVV 199

  Fly   160 INKP----HTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQ-VNNLSVMRLGKSSTLRSGEWVVA 219
            .:..    ...::|:|.:|..:.|||:|:|:.||:||:.|. ...|.|:.||.|:.||.||:|||
Mouse   200 SSSSTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATIVIHPKKKLPVLLLGHSADLRPGEFVVA 264

  Fly   220 LGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMK 284
            :|||.||.||||.|::|:.||..:|||||:.|::|:||||.|.:|||||||||||||.||:|::|
Mouse   265 IGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK 329

  Fly   285 VTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYP-VKRYMGITMLTLTPDILFELKSRSQNMP 348
            |.||||||||.|.:..||.....|..||.....|.. .||::||.|.|:||.::.|||:.:.:.|
Mouse   330 VAAGISFAIPSDRITRFLSEFQNKHVKGKELSRGADWKKRFIGIRMRTITPSLVEELKAANPDFP 394

  Fly   349 SNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQM 413
            : ::.|:.|.:|:..||:..||:|.|||:..:|.:.:.:||::.:|:.:.|..| :.:.||...:
Mouse   395 A-VSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLNESSLL-LEVRRGNDDL 457

  Fly   414 HVTITPE 420
            ..:|.||
Mouse   458 LFSIIPE 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_650366.1	DegQ	141..421	CDD:440035	131/286 (46%)
Htra3	XP_006504249.1	IGFBP	31..82	CDD:459717
		Kazal_2	<95..132	CDD:400135
		DegQ	179..457	CDD:440035	129/279 (46%)