DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and htra1

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001072730.2	Gene:	htra1 / 780187	XenbaseID:	XB-GENE-487699	Length:	460	Species:	Xenopus tropicalis

Alignment Length:	355	Identity:	163/355 - (45%)
Similarity:	231/355 - (65%)	Gaps:	31/355 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 SAAII----------QREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFS 132
            |||||          ||:..:|          |..:|||||||...|.:||:||:  .|...:|.
Frog   123 SAAIIPIQRGDCQQGQRDPDSP----------RYKYNFIADVVEKIAPAVVHIEL--FRMLPFFK 175

  Fly   133 GQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQV 197
             :.:.|::|||||:.::||||||||||.|| |.: :|..|||.|:.|.|.|||:.:|:|.::|:.
Frog   176 -REVPAASGSGFIVSEDGLILTNAHVVTNK-HRL-KVERSDGSTYDAQIIDVDEKADIALIKIKA 237

  Fly   198 -NNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAI 261
             ..|.|:.||:|..||.||:|||:|||.:|.||||.|::|:.||..:||||||.|::|:||||.|
Frog   238 KGKLPVLLLGRSEDLRPGEFVVAIGSPFSLQNTVTTGIVSTAQRGGKELGLRNSDMDYIQTDAII 302

  Fly   262 TFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMG 326
            .:|||||||||||||.||:|::|||||||||||.|.::.||..:..::..|...|.    |:|:|
Frog   303 NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIRKFLAESHNRQSTGQGTKK----KKYLG 363

  Fly   327 ITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDV 391
            |.|::|:...|.|||.:.::.|.| |.|..:.:||..:||...||:.|||:..|..|.:.:||||
Frog   364 IRMMSLSQGKLKELKEQVKDFPEN-TSGAYIVEVIPDTPAEEAGLKEGDIIISIGGKSVTSSSDV 427

  Fly   392 YDALADNSKTLDIVILRGVKQMHVTITPED 421
            .||:.....||.:||.||.:.:.:::||::
Frog   428 SDAIKKEGTTLHLVIRRGNEDIPISVTPKE 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	163/355 (46%)
		Trypsin_2	141..280	CDD:290102	82/139 (59%)
		PDZ_serine_protease	323..417	CDD:238487	36/93 (39%)
htra1	NP_001072730.2	IGFBP	26..80	CDD:365955
		KAZAL	89..>115	CDD:197624
		degP_htrA_DO	151..>459	CDD:273938	152/317 (48%)
		Serine protease	183..343		96/161 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3820
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm49269
Panther	1	1.100	-	-	O	PTHR22939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2207
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.050