Protein Alignment HtrA2 and Htra2

DIOPT Version :10

• Sequence 1: NP_650366.1
• Gene: HtrA2 / 41756
• FlyBaseID: FBgn0038233
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: NP_062726.3
• Gene: Htra2 / 64704
• MGIID: 1928676
• Length: 458
• Species: Mus musculus
• Alignment Length: 383
• Identity: 182/383 - (47%)
• Similarity: 251/383 - (65%)
• Gaps: 20/383 - (5%)

  Fly    45 GNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAII------QREDLTPTIAASKMTGRRRDF 103
            |.||...|.. ::..|.||  |.::..::||..:..::      ....:...:.|...|..|..:
Mouse    86 GTSGSSDQEA-RRSPGSRR--REWLAVAVGAGGAVVLLLWGWGRGLSTVLAAVPAPPPTSPRSQY 147

  Fly   104 NFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQ 168
            |||||||...|.:||||||.| ||  .|||:.:..||||||::..:|||:||||||.::  ..|:
Mouse   148 NFIADVVEKTAPAVVYIEILD-RH--PFSGREVPISNGSGFVVASDGLIVTNAHVVADR--RRVR 207

  Fly   169 VRLSDGRTFPATIEDVDQTSDLATLRIQVNN-LSVMRLGKSSTLRSGEWVVALGSPLALSNTVTA 232
            |||..|.|:.|.:..||..:|:||||||... |..:.||:|:.:|.||:|||:|||.||.||:|:
Mouse   208 VRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVAMGSPFALQNTITS 272

  Fly   233 GVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDY 297
            |::||.||.:::|||...::.|:||||||.||||||||||||||.||||:||||||||||||.|.
Mouse   273 GIVSSAQRPARDLGLPQNNVEYIQTDAAIDFGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDR 337

  Fly   298 VKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIV 362
            ::.||.|.   .||.|.:.|....:||:|:.||||||.||.||:.|..:.| ::.||||:.|||:
Mouse   338 LREFLHRG---EKKNSWFGTSGSQRRYIGVMMLTLTPSILIELQLREPSFP-DVQHGVLIHKVIL 398

  Fly   363 GSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPE 420
            |||||..||:|||::..|.:|..:|:.|||:|:...|: |.:.|.||.:.:.:.:|||
Mouse   399 GSPAHRAGLRPGDVILAIGEKLAQNAEDVYEAVRTQSQ-LAVRIRRGSETLTLYVTPE 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_650366.1	DegQ	141..421	CDD:440035	147/281 (52%)
Htra2	NP_062726.3	IAP-binding motif. /evidence=ECO:0000250	134..137		0/2 (0%)
		Serine protease	166..342		102/180 (57%)
		DegQ	182..455	CDD:440035	145/279 (52%)