DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and HTRA1

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_002766.1	Gene:	HTRA1 / 5654	HGNCID:	9476	Length:	480	Species:	Homo sapiens

Alignment Length:	421	Identity:	172/421 - (40%)
Similarity:	253/421 - (60%)	Gaps:	41/421 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RCIASPVLHSHAANRRSSQLAI---KEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAV 76
            :|:....:.:.|..||.:|..:   ...:|....::..| .|..|.....||..|...|
Human    88 QCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTY-ANLCQLRAASRRSERLHRP------ 145

  Fly    77 VSAAIIQR-------EDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQ 134
             ...::||       ||         ....|..:|||||||...|.:||:||:  .|... ||.:
Human   146 -PVIVLQRGACGQGQED---------PNSLRHKYNFIADVVEKIAPAVVHIEL--FRKLP-FSKR 197

  Fly   135 PITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRI-QVN 198
            .:..::|||||:.::|||:||||||.||..  |:|.|.:|.|:.|.|:|||:.:|:|.::| ...
Human   198 EVPVASGSGFIVSEDGLIVTNAHVVTNKHR--VKVELKNGATYEAKIKDVDEKADIALIKIDHQG 260

  Fly   199 NLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITF 263
            .|.|:.||:||.||.||:|||:|||.:|.||||.|::|:|||..:||||||.|::|:||||.|.:
Human   261 KLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINY 325

  Fly   264 GNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGIT 328
            |||||||||||||.||:|::|||||||||||.|.:|.||..:.:::.||.|...    |:|:||.
Human   326 GNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITK----KKYIGIR 386

  Fly   329 MLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYD 393
            |::||.....|||.|.::.| ::..|..:.:||..:||.:|||:..|::..||.:.:.:::||.|
Human   387 MMSLTSSKAKELKDRHRDFP-DVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSD 450

  Fly   394 ALADNSKTLDIVILRGVKQMHVTITPE--DP 422
            .:...| ||::|:.||.:.:.:|:.||  ||
Human   451 VIKRES-TLNMVVRRGNEDIMITVIPEEIDP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	158/364 (43%)
		Trypsin_2	141..280	CDD:290102	82/139 (59%)
		PDZ_serine_protease	323..417	CDD:238487	31/93 (33%)
HTRA1	NP_002766.1	IB	35..111	CDD:197525	5/22 (23%)
		KAZAL	115..155	CDD:197624	10/47 (21%)
		DegQ	154..480	CDD:223343	155/345 (45%)
		Serine protease	204..364		97/161 (60%)
		Trypsin_2	204..342	CDD:290102	82/139 (59%)
		PDZ_serine_protease	382..473	CDD:238487	31/92 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3884
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	301	1.000	Inparanoid score	I2690
Isobase	1	0.950	-	0	Normalized mean entropy	S5040
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm42040
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	O	PTHR22939
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2207
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.810