DRSC/TRiP Functional Genomics Resources

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Protein Alignment HtrA2 and htra1b

DIOPT Version :9

Sequence 1:NP_001262565.1 Gene:HtrA2 / 41756 FlyBaseID:FBgn0038233 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_001104652.1 Gene:htra1b / 565082 ZFINID:ZDB-GENE-080219-7 Length:476 Species:Danio rerio


Alignment Length:326 Identity:155/326 - (47%)
Similarity:223/326 - (68%) Gaps:15/326 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 RRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINKPH 164
            |..:|||||||...|.:||:||:.....|:    :.:..::||||::.::|||:||||||.||..
Zfish   163 RHRYNFIADVVEKIAPAVVHIELFRKNVFN----REVAVASGSGFVVSEDGLIVTNAHVVANKHR 223

  Fly   165 TMVQVRLSDGRTFPATIEDVDQTSDLATLRIQV-NNLSVMRLGKSSTLRSGEWVVALGSPLALSN 228
              |:|.|..|.|:.|.|:|||:.:|:|.::|.. ..|.|:.||:|:.||.||:|||:|||.:|.|
Zfish   224 --VKVELKTGTTYDAKIKDVDEKADIALIKIDAPMKLPVLLLGRSADLRPGEFVVAIGSPFSLQN 286

  Fly   229 TVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAI 293
            |||.|::|:|||..:||||||.|::|:||||.|.:|||||||||||||.||:|::||||||||||
Zfish   287 TVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAI 351

  Fly   294 PIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVW 358
            |.|.::.||..:.:::.||   ||. ..|:|:|:.|:||||.:..|||.|..:.| ::|.|..|.
Zfish   352 PSDKIRQFLAESHDRQAKG---KTA-TKKKYIGVRMMTLTPTLAKELKQRKNDFP-DVTSGAYVI 411

  Fly   359 KVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPE--D 421
            :||..:||..|||:..|::..||.:.|.::|||..|: ...::|..|:.||.:.:.:||.||  |
Zfish   412 EVIPKTPAEVGGLKESDVIISINGQRITSASDVSTAI-KTDESLRAVVRRGNEDIILTIIPEEID 475

  Fly   422 P 422
            |
Zfish   476 P 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HtrA2NP_001262565.1 DegQ 67..422 CDD:223343 153/324 (47%)
Trypsin_2 141..280 CDD:290102 80/139 (58%)
PDZ_serine_protease 323..417 CDD:238487 34/93 (37%)
htra1bNP_001104652.1 IGFBP 29..85 CDD:278641
KAZAL_FS 109..151 CDD:238052
DegQ 155..476 CDD:223343 153/324 (47%)
Serine protease. /evidence=ECO:0000250 200..360 94/161 (58%)
Trypsin_2 200..338 CDD:290102 80/139 (58%)
PDZ_serine_protease 378..469 CDD:238487 34/92 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 176 1.000 Domainoid score I3556
eggNOG 1 0.900 - - E1_COG0265
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 326 1.000 Inparanoid score I2456
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D238833at33208
OrthoFinder 1 1.000 - - FOG0000153
OrthoInspector 1 1.000 - - otm25664
orthoMCL 1 0.900 - - OOG6_100391
Panther 1 1.100 - - O PTHR22939
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2207
SonicParanoid 1 1.000 - - X265
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1211.860

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