DRSC/TRiP Functional Genomics Resources

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Protein Alignment HtrA2 and Htra1

DIOPT Version :9

Sequence 1:NP_001262565.1 Gene:HtrA2 / 41756 FlyBaseID:FBgn0038233 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_062510.2 Gene:Htra1 / 56213 MGIID:1929076 Length:480 Species:Mus musculus


Alignment Length:404 Identity:168/404 - (41%)
Similarity:240/404 - (59%) Gaps:64/404 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 AANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAIIQREDLTPT 90
            ||:|||.:|..........|..||.|::                |.||                 
Mouse   134 AASRRSEKLRQPPVIVLQRGACGQGQED----------------PNSL----------------- 165

  Fly    91 IAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDY----FSGQPITASNGSGFIIEQNGL 151
                     |..:|||||||...|.:||:||:       |    ||.:.:..::|||||:.::||
Mouse   166 ---------RHKYNFIADVVEKIAPAVVHIEL-------YRKLPFSKREVPVASGSGFIVSEDGL 214

  Fly   152 ILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRI-QVNNLSVMRLGKSSTLRSGE 215
            |:||||||.||  ..|:|.|.:|.|:.|.|:|||:.:|:|.::| ....|.|:.||:||.||.||
Mouse   215 IVTNAHVVTNK--NRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGE 277

  Fly   216 WVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGV 280
            :|||:|||.:|.||||.|::|:|||..:||||||.|::|:||||.|.:|||||||||||||.||:
Mouse   278 FVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGI 342

  Fly   281 NSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQ 345
            |::|||||||||||.|.:|.||..:.:::.||.|...    |:|:||.|::||.....|||.|.:
Mouse   343 NTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTK----KKYIGIRMMSLTSSKAKELKDRHR 403

  Fly   346 NMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGV 410
            :.|..|: |..:.:||..:||.:|||:..|::..||.:.:..::||.|.: ....||::|:.||.
Mouse   404 DFPDVLS-GAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVI-KKENTLNMVVRRGN 466

  Fly   411 KQMHVTITPE--DP 422
            :.:.:|:.||  ||
Mouse   467 EDIVITVIPEEIDP 480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HtrA2NP_001262565.1 DegQ 67..422 CDD:223343 156/361 (43%)
Trypsin_2 141..280 CDD:290102 82/139 (59%)
PDZ_serine_protease 323..417 CDD:238487 31/93 (33%)
Htra1NP_062510.2 IB 37..111 CDD:197525
KAZAL 115..155 CDD:197624 7/20 (35%)
DegQ 154..480 CDD:223343 159/382 (42%)
Serine protease 204..364 97/161 (60%)
Trypsin_2 204..342 CDD:290102 82/139 (59%)
PDZ_serine_protease 382..473 CDD:238487 31/92 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 167 1.000 Domainoid score I3841
eggNOG 1 0.900 - - E1_COG0265
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5040
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D238833at33208
OrthoFinder 1 1.000 - - FOG0000153
OrthoInspector 1 1.000 - - otm44093
orthoMCL 1 0.900 - - OOG6_100391
Panther 1 1.100 - - O PTHR22939
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2207
SonicParanoid 1 1.000 - - X265
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.760

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