DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HtrA2 and Htra3

DIOPT Version :9

Sequence 1:NP_001262565.1 Gene:HtrA2 / 41756 FlyBaseID:FBgn0038233 Length:422 Species:Drosophila melanogaster
Sequence 2:NP_001257956.1 Gene:Htra3 / 360959 RGDID:1308120 Length:459 Species:Rattus norvegicus


Alignment Length:331 Identity:150/331 - (45%)
Similarity:221/331 - (66%) Gaps:17/331 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 KMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVV 159
            ::|..|..||||||||...|.:||:||: ..||  ...|:.:..|:|||||:.:.|||:||||||
  Rat   138 QLTSPRYKFNFIADVVEKIAPAVVHIEL-FLRH--PLFGRNVPLSSGSGFIMSEAGLIVTNAHVV 199

  Fly   160 IN----KPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVN-NLSVMRLGKSSTLRSGEWVVA 219
            .:    .....::|:|.:|..:.|||:|:|:.||:||:.|..| .|.|:.||.|:.||.||:|||
  Rat   200 SSSNTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATILIHPNKKLPVLLLGHSADLRPGEFVVA 264

  Fly   220 LGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMK 284
            :|||.||.||||.|::|:.||..:|||||:.|::|:||||.|.:|||||||||||||.||:|::|
  Rat   265 IGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLK 329

  Fly   285 VTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPS 349
            |.||||||||.|.:..||....:|..|.  :|     ||::||.|.|:||.::.|||:.:.:.|:
  Rat   330 VAAGISFAIPSDRITRFLSEFQDKHVKD--WK-----KRFIGIRMRTITPSLVEELKTANPDFPA 387

  Fly   350 NLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMH 414
             ::.|:.|.:|:..||:..||:|.|||:..:|.:.:.:||::.:|:.:.|..| :.:.||...:.
  Rat   388 -VSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLNESSLL-LEVRRGNDDLL 450

  Fly   415 VTITPE 420
            .:|.||
  Rat   451 FSIMPE 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HtrA2NP_001262565.1 DegQ 67..422 CDD:223343 150/331 (45%)
Trypsin_2 141..280 CDD:290102 79/143 (55%)
PDZ_serine_protease 323..417 CDD:238487 30/93 (32%)
Htra3NP_001257956.1 IGFBP 31..82 CDD:278641
Kazal_2 87..132 CDD:284958
Serine protease. /evidence=ECO:0000250 181..346 92/164 (56%)
Trypsin_2 181..325 CDD:290102 79/143 (55%)
PDZ_serine_protease 361..446 CDD:238487 29/86 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 167 1.000 Domainoid score I3754
eggNOG 1 0.900 - - E1_COG0265
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D238833at33208
OrthoFinder 1 1.000 - - FOG0000153
OrthoInspector 1 1.000 - - otm46186
orthoMCL 1 0.900 - - OOG6_100391
Panther 1 1.100 - - O PTHR22939
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X265
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.780

Return to query results.
Submit another query.