DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and Htra4

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_036010000.1	Gene:	Htra4 / 330723	MGIID:	3036260	Length:	499	Species:	Mus musculus

Alignment Length:	358	Identity:	146/358 - (40%)
Similarity:	214/358 - (59%)	Gaps:	64/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 VPFSLGAVVSAAIIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSG 133
            ||...||...|.         |..|.::   ||.:||||.||...|.|||::::        |..
Mouse   197 VPVQKGACEEAG---------TTRAGRL---RRKYNFIAAVVEKVAPSVVHLQL--------FRR 241

  Fly   134 QPIT-----ASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATL 193
            .|:|     :|:|||||:.::|||:|||||:.|:  ..:||.|..|..:.||::|:|...|||.:
Mouse   242 SPLTNQEIPSSSGSGFIVSEDGLIVTNAHVLTNQ--QKIQVELQSGARYEATVKDIDHKLDLALI 304

  Fly   194 RIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTD 258
            :|:.:                             ||||||::|:|||..:||||:|.||:|:|||
Mouse   305 KIEPD-----------------------------NTVTAGIVSTTQRGGRELGLKNSDIDYIQTD 340

  Fly   259 AAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPV-K 322
            |.|..||||||||||||:.||:|::|||||||||||.|.::.|||...|::.||.|     |: |
Mouse   341 AIINHGNSGGPLVNLDGDVIGINTLKVTAGISFAIPSDRIRQFLEDYHERQLKGKA-----PLQK 400

  Fly   323 RYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKN 387
            :|:|:.||.||.::|.|:|.:....| :::.||.|::||.||.|.|.||:..|::..||.:.:..
Mouse   401 KYLGLRMLPLTLNLLQEMKRQDPEFP-DVSSGVFVYEVIQGSAAASSGLRDHDVIVSINGQPVTT 464

  Fly   388 SSDVYDALADNSKTLDIVILRGVKQMHVTITPE 420
            ::||.:|:.||. .|.|::|||.:.:.:|:|||
Mouse   465 TTDVIEAVKDND-FLSIIVLRGSQTLFLTVTPE 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	146/358 (41%)
		Trypsin_2	141..280	CDD:290102	62/138 (45%)
		PDZ_serine_protease	323..417	CDD:238487	34/93 (37%)
Htra4	XP_036010000.1	IGFBP	85..139	CDD:395164
		Kazal_2	156..204	CDD:400135	3/6 (50%)
		degP_htrA_DO	222..>494	CDD:273938	132/317 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	167	1.000	Domainoid score	I3841
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm44093
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	O	PTHR22939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.780