DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and Htra2

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_001100069.1	Gene:	Htra2 / 297376	RGDID:	1308906	Length:	458	Species:	Rattus norvegicus

Alignment Length:	402	Identity:	185/402 - (46%)
Similarity:	256/402 - (63%)	Gaps:	25/402 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSQLAIKEGDPN-----SNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAAII------QR 84
            :|:..:..|.|:     :.|..|...|. :....|.||  |.::..:|||..:..::      ..
  Rat    67 ASRANLTSGTPDLWVRLTVGTPGSSDQE-DCGSPGSRR--REWLAVALGAGGAVLLLLWGWGRGP 128

  Fly    85 EDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQN 149
            ..:...:.|...|..|..:|||||||...|.:||||||.| ||  .|||:.:..|||||||:..:
  Rat   129 STVLAAVPAPPPTSPRSQYNFIADVVEKTAPAVVYIEILD-RH--PFSGREVPISNGSGFIVASD 190

  Fly   150 GLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNN-LSVMRLGKSSTLRS 213
            |||:||||||.::  ..|:|||..|.|:.|.:..||..:|:||||||... |..:.||:|:.:|.
  Rat   191 GLIVTNAHVVADR--RRVRVRLPSGDTYEAMVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQ 253

  Fly   214 GEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAI 278
            ||:|||:|||.||.||:|:|::||.||.:::|||...::.|:||||||.||||||||||||||.|
  Rat   254 GEFVVAMGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVI 318

  Fly   279 GVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSR 343
            |||:||||||||||||.|.::.||.|.   .||.|.:......:||:|:.||||||.||.||:.|
  Rat   319 GVNTMKVTAGISFAIPSDRLREFLHRG---EKKNSWFGISGSQRRYIGVMMLTLTPSILAELQLR 380

  Fly   344 SQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILR 408
            ..:.| ::.||||:.|||:|||||..||:|.|::..|.:|.|:|:.|||:|:...|: |.:.|.|
  Rat   381 EPSFP-DVQHGVLIHKVILGSPAHRAGLRPADVILAIGEKMIQNAEDVYEAVRTQSQ-LAVRIRR 443

  Fly   409 GVKQMHVTITPE 420
            |.:.:.:.:|||
  Rat   444 GPETLTLYVTPE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	175/361 (48%)
		Trypsin_2	141..280	CDD:290102	78/139 (56%)
		PDZ_serine_protease	323..417	CDD:238487	44/93 (47%)
Htra2	NP_001100069.1	DegQ	140..454	CDD:223343	168/323 (52%)
		Trypsin_2	182..320	CDD:290102	78/139 (56%)
		PDZ_serine_protease	360..452	CDD:238487	44/93 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339827
Domainoid	1	1.000	167	1.000	Domainoid score	I3754
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H113300
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2544
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm46186
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	LDO	PTHR22939
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760