DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and SPBC1685.05

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	NP_595209.1	Gene:	SPBC1685.05 / 2539936	PomBaseID:	SPBC1685.05	Length:	997	Species:	Schizosaccharomyces pombe

Alignment Length:	366	Identity:	85/366 - (23%)
Similarity:	154/366 - (42%)	Gaps:	88/366 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 NFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGS----GFIIEQN-GLILTNAHVVINKP 163
            |.|.:||.    |:|.|:....|.||       |.|.||    ||::.:. ||||:|.|||...|
pombe    69 NTIKNVVR----SIVSIKGSALRSFD-------TESAGSFCATGFVVNKTLGLILSNRHVVSPGP 122

  Fly   164 HTMVQVRLSDGRTFPATIEDV-------DQTSDLATLR-----IQVNNLSVMRLGKSSTLRSGEW 216
                   :|...:| ...|::       |...|....|     |:.::::.:.|...|. :.|..
pombe   123 -------ISARASF-INYEEIDIYPIYRDPVHDFGFFRYDPSSIRFHDVTEISLSPESA-KVGID 178

  Fly   217 VVALGSPLALSNTVTAGVISSTQRASQELGLRN-RDIN--YLQTDAAITFGNSGGPLVNLDGEAI 278
            :..:|:......::.:..::...|.:...|:.| .|.|  |.|..:..:.|:||.|::::.|.|:
pombe   179 IRIIGNDAGEKLSILSSTLARLDRPAPNYGIDNYNDFNTFYYQAASGTSGGSSGSPVLDISGAAV 243

  Fly   279 GVNS-MKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYPVKR-----------YMGITMLT 331
            .:|| ...::..||.:|:|.| |...|..|...         |:.|           |..::.:.
pombe   244 ALNSGGSNSSASSFYLPLDRV-VRALRCIENNT---------PITRGTLLTEFLHWSYDELSRIG 298

  Fly   332 LTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNS-------- 388
            |..:..::.::|   :||:.  |:||...::.:...|..|:||||:........|::
pombe   299 LPREFEYDCRTR---VPSST--GLLVVSRVLRNSEVSKALEPGDILIAFKTDSHKSTYIVDFVSL 358

  Fly   389 SDVYDALADNSKTLDIVILR----------GVKQMHVTITP 419
            .:|.|.:.  .||:::.:.|          .|:.:| .:||
pombe   359 FEVLDEMV--GKTIELHVYRPKRGFLTFQLTVQDLH-NVTP 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	85/366 (23%)
		Trypsin_2	141..280	CDD:290102	37/158 (23%)
		PDZ_serine_protease	323..417	CDD:238487	23/122 (19%)
SPBC1685.05	NP_595209.1	DegQ	66..397	CDD:223343	85/366 (23%)
		Trypsin_2	99..245	CDD:290102	35/154 (23%)
		PDZ_1	394..469	CDD:289574	2/3 (67%)
		PDZ	<814..855	CDD:294084
		PDZ	<893..963	CDD:294084
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860