DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and htra2

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_031750958.1	Gene:	htra2 / 100492982	XenbaseID:	XB-GENE-6044196	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	324	Identity:	169/324 - (52%)
Similarity:	229/324 - (70%)	Gaps:	8/324 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 GRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVINK 162
            |.|:.|||||||....|.:||.|||.| ||  .||.:.:..|:||||::..:|||:||||||.|:
Frog   117 GGRKYFNFIADVAERTAPAVVNIEILD-RH--PFSRREVAVSSGSGFLVSPDGLIVTNAHVVANR 178

  Fly   163 PHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVN-NLSVMRLGKSSTLRSGEWVVALGSPLAL 226
              ..|:|:||:|.::.|.:.|||..:|:||::|... .|..:|||:|:.:|.||:|||:|||.:|
Frog   179 --RRVRVKLSNGESYEAAVRDVDPATDIATIKINPKVPLPTLRLGRSAEIRQGEFVVAMGSPFSL 241

  Fly   227 SNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISF 291
            .||:|:|::||.||...||||.|||:.|:||||||.||||||||||||||.||:|:|||..||||
Frog   242 QNTITSGIVSSVQRGGHELGLANRDMEYIQTDAAIDFGNSGGPLVNLDGEVIGINTMKVVPGISF 306

  Fly   292 AIPIDYVKVFLERAAEKRKKGSAYKTGYPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVL 356
            |||.|.|:.||:...::|.:||...:....:||:|:.||||||.||.|||.|..:.| :::||||
Frog   307 AIPSDRVREFLQHGEKRRSQGSLLGSSEVKRRYIGVMMLTLTPKILAELKFRDPSFP-DVSHGVL 370

  Fly   357 VWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITPE 420
            :.|||||||||..||:.||:|..||.|....|.|:|||:..:.| |.:::.||.:.:.||:.||
Frog   371 IHKVIVGSPAHESGLRAGDVVLEINAKRAMTSEDIYDAVHTHPK-LTMIVRRGSESLMVTVIPE 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	169/324 (52%)
		Trypsin_2	141..280	CDD:290102	79/139 (57%)
		PDZ_serine_protease	323..417	CDD:238487	47/93 (51%)
htra2	XP_031750958.1	degP_htrA_DO	125..>431	CDD:273938	162/312 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3820
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	317	1.000	Inparanoid score	I2497
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm49269
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060