DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HtrA2 and htra4

DIOPT Version :9

Sequence 1:	NP_001262565.1	Gene:	HtrA2 / 41756	FlyBaseID:	FBgn0038233	Length:	422	Species:	Drosophila melanogaster
Sequence 2:	XP_017211746.2	Gene:	htra4 / 100334257	ZFINID:	ZDB-GENE-131120-192	Length:	459	Species:	Danio rerio

Alignment Length:	426	Identity:	167/426 - (39%)
Similarity:	245/426 - (57%)	Gaps:	48/426 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQY-------QQNGEQKEKGWR 62
            |..||.|    |.|.......:|.|  |.......:|....:...|       .:|...|..|
Zfish    67 GEDRLGV----CGAGMTCEERSAER--STCVCDSHEPVCGSDGRTYPSICRLKAENRRAKTSG-- 123

  Fly    63 RLVRFFVPFSLGAVVSAAIIQREDLTPTIAASK-MTGRRRDFNFIADVVAGCADSVVYIEIKDTR 126
                  :|    ||:   .|||   .|....|: .:..|..||||||||...|.:||::|:
Zfish   124 ------IP----AVI---FIQR---GPCETGSRNPSSMRYKFNFIADVVDKIAPAVVHLEL---- 168

  Fly   127 HFDY--FSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSD 189
             |..  ||.|.:..|:|||||:.::|.|:|||||:.||..  ::|.|.:|..:.|||:||||..|
Zfish   169 -FSRLPFSNQDVPVSSGSGFIVSEDGWIVTNAHVLSNKQR--IKVELKNGMLYDATIKDVDQKLD 230

  Fly   190 LATLRIQVNN-LSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDIN 253
            :|.::|.... |.|:.||:||.||.||:|||:|||.:|.||||.|:||:|.|...||||:|.|:.
Zfish   231 IALIKIDSETALPVLLLGRSSDLRPGEFVVAVGSPFSLQNTVTTGIISTTHRGGHELGLQNSDME 295

  Fly   254 YLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTG 318
            |:||||.|.:||||||||||||:.||:|::|||.|||||||.|.::.||..:.|:::||.....
Zfish   296 YIQTDAIINYGNSGGPLVNLDGDVIGINTLKVTPGISFAIPSDRIRQFLADSYERQRKGRTLTK- 359

  Fly   319 YPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKK 383
               |:|||:.||.|:..::.||:.:..:.| :::.||.|::||.|:.|.|.|:...|::..||.:
Zfish   360 ---KKYMGVRMLQLSAALIRELREKESSFP-DVSSGVYVYEVIPGTAAFSAGMLNQDVIISINGQ 420

  Fly   384 EIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITP 419
            .:.::.||..|:..| :.|.:::.|..|::.:|:.|
Zfish   421 PVYSTEDVSQAVQSN-EILSLMVRRAQKEITLTVVP 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_001262565.1	DegQ	67..422	CDD:223343	153/357 (43%)
		Trypsin_2	141..280	CDD:290102	78/139 (56%)
		PDZ_serine_protease	323..417	CDD:238487	28/93 (30%)
htra4	XP_017211746.2	IGFBP	27..80	CDD:306685	6/16 (38%)
		KAZAL_FS	92..135	CDD:238052	11/60 (18%)
		DegQ	118..459	CDD:223343	155/369 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3556
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	326	1.000	Inparanoid score	I2456
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D238833at33208
OrthoFinder	1	1.000	-	-		FOG0000153
OrthoInspector	1	1.000	-	-		otm25664
orthoMCL	1	0.900	-	-		OOG6_100391
Panther	1	1.100	-	-	O	PTHR22939
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X265
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830