Protein Alignment HtrA2 and htra4

DIOPT Version :10

• Sequence 1: NP_650366.1
• Gene: HtrA2 / 41756
• FlyBaseID: FBgn0038233
• Length: 422
• Species: Drosophila melanogaster
• Sequence 2: XP_017211746.2
• Gene: htra4 / 100334257
• ZFINID: ZDB-GENE-131120-192
• Length: 459
• Species: Danio rerio
• Alignment Length: 426
• Identity: 167/426 - (39%)
• Similarity: 245/426 - (57%)
• Gaps: 48/426 - (11%)

  Fly     5 GSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQY-------QQNGEQKEKGWR 62
            |..||.|    |.|.......:|.|  |.......:|....:...|       .:|...|..|
Zfish    67 GEDRLGV----CGAGMTCEERSAER--STCVCDSHEPVCGSDGRTYPSICRLKAENRRAKTSG-- 123

  Fly    63 RLVRFFVPFSLGAVVSAAIIQREDLTPTIAASK-MTGRRRDFNFIADVVAGCADSVVYIEIKDTR 126
                  :|    ||:   .|||   .|....|: .:..|..||||||||...|.:||::|:
Zfish   124 ------IP----AVI---FIQR---GPCETGSRNPSSMRYKFNFIADVVDKIAPAVVHLEL---- 168

  Fly   127 HFDY--FSGQPITASNGSGFIIEQNGLILTNAHVVINKPHTMVQVRLSDGRTFPATIEDVDQTSD 189
             |..  ||.|.:..|:|||||:.::|.|:|||||:.||..  ::|.|.:|..:.|||:||||..|
Zfish   169 -FSRLPFSNQDVPVSSGSGFIVSEDGWIVTNAHVLSNKQR--IKVELKNGMLYDATIKDVDQKLD 230

  Fly   190 LATLRIQVNN-LSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDIN 253
            :|.::|.... |.|:.||:||.||.||:|||:|||.:|.||||.|:||:|.|...||||:|.|:.
Zfish   231 IALIKIDSETALPVLLLGRSSDLRPGEFVVAVGSPFSLQNTVTTGIISTTHRGGHELGLQNSDME 295

  Fly   254 YLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTG 318
            |:||||.|.:||||||||||||:.||:|::|||.|||||||.|.::.||..:.|:::||.....
Zfish   296 YIQTDAIINYGNSGGPLVNLDGDVIGINTLKVTPGISFAIPSDRIRQFLADSYERQRKGRTLTK- 359

  Fly   319 YPVKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKK 383
               |:|||:.||.|:..::.||:.:..:.| :::.||.|::||.|:.|.|.|:...|::..||.:
Zfish   360 ---KKYMGVRMLQLSAALIRELREKESSFP-DVSSGVYVYEVIPGTAAFSAGMLNQDVIISINGQ 420

  Fly   384 EIKNSSDVYDALADNSKTLDIVILRGVKQMHVTITP 419
            .:.::.||..|:..| :.|.:::.|..|::.:|:.|
Zfish   421 PVYSTEDVSQAVQSN-EILSLMVRRAQKEITLTVVP 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HtrA2	NP_650366.1	DegQ	141..421	CDD:440035	127/280 (45%)
htra4	XP_017211746.2	IGFBP	27..80	CDD:459717	6/16 (38%)
		Kazal_2	88..135	CDD:400135	12/64 (19%)
		DegQ	182..457	CDD:440035	128/282 (45%)